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Crescentic infection related glomerulonephritis in adult and its outcome
Joint Authors
Gopalakrishnan, Natarajan
Dineshkumar, Thanigachalam
Sakthirajan, Ramanathan
Balasubramaniyan, T.
Dhanapriya, Jeyachandran
Nagarajan, Mani
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 3 (30 Jun. 2018), pp.623-629, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-06-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
The epidemiology of infection-related glomerulonephritis (IRGN) is changing in recent times both in developed and developing nations.
Although published studies showed renal outcome in adult IRGN was not as benign as in children, literature regarding clinical profile and outcome of crescentic form of adult IRGN is scarce; hence, we aimed to study the clinical profile of crescentic IRGN.
We conducted a retrospective observational study in patients with crescentic IRGN in adults at the Department of Nephrology, Madras medical college, Chennai between 2009 and 2014.
A total of 47 patients were included with a mean follow-up of 9.9 ± 4.2 months.
The mean age was 42 ± 13.5 years.
About 19.1% of patients had diabetes.
The skin was the most common site of infection (38.3%) with methicillin-resistant Staphylococcus aureus (MRSA) as the most common organism.
Hypocomplementemia was present in 100% in our study.
Hemodialysis (HD) was required in 53.2% of patients and oral steroids were given in 78.7%.
Complete renal recovery was seen only in 25.5%, progression to chronic kidney disease in 40.4%, seven patients reached end-stage renal disease, and nine patients died during follow-up.
On univariate analysis, MRSA infection, the unidentified source of infection, nonisolation of organisms presence of interstitial fibrosis and tubular atrophy in renal biopsy and requirement of HD were found to be significant risk factors for poor renal outcome.
In our study, crescentic form of IRGN is associated with poor renal outcome.
American Psychological Association (APA)
Sakthirajan, Ramanathan& Dhanapriya, Jeyachandran& Nagarajan, Mani& Dineshkumar, Thanigachalam& Balasubramaniyan, T.& Gopalakrishnan, Natarajan. 2018. Crescentic infection related glomerulonephritis in adult and its outcome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 3, pp.623-629.
https://search.emarefa.net/detail/BIM-839184
Modern Language Association (MLA)
Sakthirajan, Ramanathan…[et al.]. Crescentic infection related glomerulonephritis in adult and its outcome. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 3 (Jun. 2018), pp.623-629.
https://search.emarefa.net/detail/BIM-839184
American Medical Association (AMA)
Sakthirajan, Ramanathan& Dhanapriya, Jeyachandran& Nagarajan, Mani& Dineshkumar, Thanigachalam& Balasubramaniyan, T.& Gopalakrishnan, Natarajan. Crescentic infection related glomerulonephritis in adult and its outcome. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 3, pp.623-629.
https://search.emarefa.net/detail/BIM-839184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 629
Record ID
BIM-839184