Albuminuria status and patterns of dyslipidemia among type 2 diabetes black patients managed at a tertiary health-care hospital : a post hoc analysis

Abstract EN

Cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) increases with the development of albuminuria and is related in part to dyslipidemia.

The present analysis assessed lipid profile and patterns of dyslipidemia in T2DM patients according to albuminuria status.

This was a post hoc analysis of data from 181 T2DM patients seen at a tertiary health-care hospital and enrolled in a cross-sectional study of albuminuria status.

Abnormal albuminuria was defined as microalbuminuria [albumin to creatinine ratio (ACR) 30–299.9 mg/g] or macroalbuminuria (ACR ≥300 mg/g).

Atherogenic dyslipidemia was defined as triglycerides (TGs) ≥150 mg/dL and/or high-density lipoprotein-cholesterol (HDL-c) <40 mg/dL in men and <50 mg/dL in women using international consensus criteria.

High levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), HDL-c, non-HDL-c, TG, and low level of HDL-c were defined according to 2012 American Association of Clinical Endocrinologists’ guidelines.

Comparisons between T2DM patients with and without abnormal albuminuria were done using Chi-square test, Student’s t-test, or two-sample t-test with equal variance and Mann–Whitney test as appropriate.

P < 0.05 defined the level of statistical significance.

Of the 181 T2DM patients, 93 (51%) had abnormal albuminuria with 32% and 19% having microalbuminuria and macroalbuminuria, respectively.

Average TC, HDL-c, HDL-c, non-HDL-c, and TG levels were 171 ± 41, 111 ± 36, 38 ± 16, 133 ± 38, and 98 (45–234) mg/dL, respectively.

These values were significantly lower for TC (P = 0.047), LDL-c (P = 0.030), and non-HDL-c (P = 0.05) in comparison with patients with normal albuminuria.

Low HDL-c (64.5%) and high TG (9.7%) were,