Evaluation of the effect of local exogenous application of osteopontin on wound healing in rats
Joint Authors
al-Zamily, Zahra Rahim
Kazim, Inas Fadil
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 30, Issue 2 (30 Jun. 2018), pp.23-28, 6 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background : Wound healing is a complex dynamical interaction between various cell types, the extracellular matrix, cytokines, and growth factors.
osteoponetin is a substance that acts as an anti-inflammatory.
Aims of study: The study was designed to identify the role of local exogenous applications of osteopontin on wound healing (in cheek skin).
Materials and methods : Thirty adult male albino rats weighting an average of (250-300gm) used in this study, incisional wounds were made in the skin of the cheek of rat and they were divided into the following groups: A-Control group: 15 rats treated with 1μ l of normal saline B-Experimental groups: 15 rats treated with topical application of 1μl osteopontin.
The scarification of animals were done for the healing intervals (1, 5 and 10 days) Histological analysis and assessment of number of inflammatory cell, Thickness and contraction of incision were performed for both experimental and control groups for all healing periods.
Results : Histological analysis revealed that osteopontin accelerate wound healing of cheek skin and there was highly significant difference among studied groups in periods 1,5,10 days.
Regarding mean values of epithelial thickness, inflammatory cell count and contraction of wound area have reported a highest value different in 1, 5 and 10 days durations.
Conclusion : It can be concluded that application of osteopontin shown efficacy in the healing of skin wounds induced in rats.
American Psychological Association (APA)
al-Zamily, Zahra Rahim& Kazim, Inas Fadil. 2018. Evaluation of the effect of local exogenous application of osteopontin on wound healing in rats. Journal of Baghdad College of Dentistry،Vol. 30, no. 2, pp.23-28.
https://search.emarefa.net/detail/BIM-839884
Modern Language Association (MLA)
al-Zamily, Zahra Rahim& Kazim, Inas Fadil. Evaluation of the effect of local exogenous application of osteopontin on wound healing in rats. Journal of Baghdad College of Dentistry Vol. 30, no. 2 (Jun. 2018), pp.23-28.
https://search.emarefa.net/detail/BIM-839884
American Medical Association (AMA)
al-Zamily, Zahra Rahim& Kazim, Inas Fadil. Evaluation of the effect of local exogenous application of osteopontin on wound healing in rats. Journal of Baghdad College of Dentistry. 2018. Vol. 30, no. 2, pp.23-28.
https://search.emarefa.net/detail/BIM-839884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 28
Record ID
BIM-839884