Histopathological changes that induced in the internal organs of white rat after exposure to Diazinon

Abstract EN

A pesticide diazinon is a widely used and easily available in the world so, the general health risks of this compound for environment, human and animals were investigated with emphasis on histopathological effects by oral gavage Sixteen adults laboratory rats from tow sex with diazinon solution for about six weeks.

The animals were divided into two groups with (8)animal in each group.

The control group was given orally distill water, while the experimental group was given high dose of diazinon 10mg/ml for the first three weeks and up to 20mg/ml for the last three weeks.

The most important histopathological changes observed in the internal organs(liver,kidney,heart muscle, lung, stomach and nervous tissue) of the experimental rat include congestion,degeneration, fibrosis, necrosis, vaculation and edema in compared with the control animals.