Biochemical risk determinants of osteoporosis in overweight and obese postmenopausal women with type 2 diabetes mellitus
Author
Source
al-Kindy College Medical Journal
Issue
Vol. 14, Issue 1 (30 Jun. 2018), pp.33-36, 4 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Abstract EN
Background: Several studies suggested that skeletal system is adversely affected by diabetes and is associated with increased risk of osteoporosis and fragility fractures Objectives: The study was a case-control study that designed to assess the level of bone turnover markers (BTMs) among patients with type 2 diabetes mellitus (T2DM) and to investigate the effect of body weight and diabetic control on the level of bone turnover Type of the study: Cross- sectional study.
Methods: The present study included 100 postmenopausal women with type 2 diabetes mellitus.
Sixty-six non-diabetic postmenopausal women were enrolled as a control.
Fasting blood samples were collected to measure Alkaline phosphatase (ALP),stoeocalcin(OC), fasting blood sugar (FBS)and glycated hemoglobin (HbA1c).
Urine samples were collected to measure deoxypyridinolin(DPD).
The results were expressed as a ratio to urine creatinine Results: The mean level of serum osteocalcin was significantly lower in the diabetic group than in the control group,while the level of urinary deoxypyridinolin was significantly higher in the diabetic group than in the control group .
There was no significant difference in the level of Alkaline phosphatase between diabetic patients and control.
An inverse association was found between osteocalcin with body mass index(BMI), glycated hemoglobin and fasting blood sugar.
On the other hand appositive association was found between the level of deoxypyridinolin with body mass index Conclusions: Altered bone metabolic markers in patients with T2DM with more significant alterations in those who hsd poor glycemic control .
Decrease in formation marker osteocalcin and increased resorption markers such as (DPD) has been found.
American Psychological Association (APA)
Ibrahim, Ikhlas H.. 2018. Biochemical risk determinants of osteoporosis in overweight and obese postmenopausal women with type 2 diabetes mellitus. al-Kindy College Medical Journal،Vol. 14, no. 1, pp.33-36.
https://search.emarefa.net/detail/BIM-840161
Modern Language Association (MLA)
Ibrahim, Ikhlas H.. Biochemical risk determinants of osteoporosis in overweight and obese postmenopausal women with type 2 diabetes mellitus. al-Kindy College Medical Journal Vol. 14, no. 1 (2018), pp.33-36.
https://search.emarefa.net/detail/BIM-840161
American Medical Association (AMA)
Ibrahim, Ikhlas H.. Biochemical risk determinants of osteoporosis in overweight and obese postmenopausal women with type 2 diabetes mellitus. al-Kindy College Medical Journal. 2018. Vol. 14, no. 1, pp.33-36.
https://search.emarefa.net/detail/BIM-840161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 36
Record ID
BIM-840161