Study the effect of bay leaf extracton the somebiochemical parameters in diabetic male rat induced by alloxan

Abstract EN

The present study aimed to determine the ameliorative effect of bay leaf extract(BLE) on some biochemical parameters of laboratory diabetic male rats (Rattusnorvegicas) induced by Alloxan .The study consisted of thirty adult male rats randomly divided into five equal group(six of each ).

As follow :Group one the animals treated by intra peritoneal injection (IP) of normal saline solution (0.25ml),Group two the animal treated by oral gavage with (BLE) at dose (500 mg /Kg/BW) daily .Group three , rats were treated I.P with 100 mg /Kg BW single dose of alloxan(Allox).Group four .The diabetic rats were given orally by oral gavage low dose of ( BLE)(250 mg /Kg/BW ) daily.

Group five ,diabetic rats were given by oral gavage high dose of BLE(500 mg /Kg/BW ) daily for 3 weeks.At the end of experiments period ,rats were sacrificed ,blood were collected by cardiac puncture to investigate biochemical parameters which included glucose ,liver enzyme (ALT,AST and ALP ) lipid profile TG , TC ,HDL-c , LDL-c , ,Total serum protein, Blood urea, and Creatinine concentration .

Result indicated a significant increased in Glucose,ALT, AST, ALP, TC, TG, LDL-c ,urea, and Creatinineinin diabetic animal whereas HDL-c significantly decreased