New perspective in studying propofol and sleep interaction : a pilot study

Abstract EN

Several studies suggested that propofol satisfied the need for both rapid eye movement (REM) and slow wave sleep (SWS).

Most of these studies were based either on animal models or on induced sleep deprivation without further clinical extrapolation.

The this preliminary study investigated the relation between natural preoperative sleep (REM and SWS) and operative propofol induction dose, whether or not clinical impact can be extracted from this relation, and finally to assess the feasibility of conducting a similar full-scale trial.

This study was a prospective observational study.

27 ASA I adult male patients scheduled for elective surgery were subjected to preoperatively sleep EEG.

Propofol induction dose achieving Bispectral Index (BIS) value between 40 and 60 was recorded.

Correlation between propofol dose and both SWS % and REM % was done.

Patients were classified according to sleep EEG into good sleepers and bad sleepers.

Propofol dose in good sleepers and bad sleepers was compared.

The results showed a positive correlation between propofol induction dose and both SWS (%) (r= 0.532; p= 0.003) and REM (%) (r= 0.518; p= 0.005).The median value of propofol induction dose in good sleepers was 1.70 (1.00-2.00), while in bad sleepers it was significantly lower 1.10 (0.80-1.70) (p value = 0.01)