Role of oxidized low-density lipoprotein in hepatitis C related chronic liver disease

Abstract EN

Hepatitis C virus(HCV) lifecycle is closely connected to host cell lipid metabolism, inducing oxidative stress and oxidation reaction induce chemical modification of proteins and lipids in plasma LDL transforming it to abnormal oxidized-LDL (Ox-LDL).

Ox-LDL is more stable marker molecule with longer half-life than free radicals.

This study assessed its contribution to the pathogenesis of liver diseases, and liver cirrhosis.

This work studied serum level of ox-LDL to evaluate its role in chronic hepatitis C patients and its association with liver cirrhosis.

Also, the level of serum total antioxidant status was determined to evaluate their role in the treatment.

The study included 20 chronic hepatitis C patients, 20 chronic hepatitis C patients with liver cirrhosis and 20 controls (age, sex & anthropometric measures were matched).

All patients and controls were males.

Serum was used to estimate Ox-LDL total direct bilirubin, albumin, aminotransferases, total antioxidant capacity, Urea and creatinine