Systemic granisetron can minimize hypotension and bradycardia during spinal anesthesia in patients undergoing elective lower-abdominal surgeries : a prospective, double-blind randomized controlled study
Joint Authors
Ammar, Muna A.
Abd Allah, Walid
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 10, Issue 1 (31 Mar. 2017), pp.247-252, 6 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2017-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction Although it is considered safe, spinal anesthesia has many side effects, including hypotension, and bradycardia.
Increased activity of chemoreceptors (Bezold–Jarisch reflex) may play a role in this.
The release of serotonin has been suggested as a possible trigger for Bezold–Jarisch reflex.
Granisetron, a selective 5-HT3 receptor antagonist, may play a role in preventing hypotension and bradycardia.
Aim The aim of this study was to assess the effects of granisetron on hypotension, bradycardia, shivering, nausea, and vomiting after spinal anesthesia in patients undergoing elective lower-abdominal surgeries.
Patients and methods This study was designed as a randomized, double-blind, placebo-controlled trial.
Fifty-four American Society of Anesthesiologists I–III patients, ages 25–55 years, scheduled for elective lower-abdominal surgeries under spinal anesthesia were included in this prospective study and were divided into two equal groups.
Group G received 1 mg intravenous granisetron diluted in 0.9% normal saline to a total volume of 5 ml, and group C received 5 ml normal saline 5 min before undergoing spinal anesthesia.
The mean arterial blood pressure, the heart rate, nausea, vomiting, and shivering were assessed.
Results The reduction in mean arterial blood pressure and heart rate was significantly lower in group G compared with group C.
Regarding the incidence of complications, hypotension, bradycardia, nausea, and shivering were significantly lower in group G compared with group C.
No significant difference was observed with regard to the incidence of vomiting.
Conclusion In lower-abdominal surgery, intravenously 1 mg granisetron before subarachnoid block decreased the incidence of hypotension and bradycardia significantly, besides being effective for the prevention of nausea, vomiting, and shivering
American Psychological Association (APA)
Abd Allah, Walid& Ammar, Muna A.. 2017. Systemic granisetron can minimize hypotension and bradycardia during spinal anesthesia in patients undergoing elective lower-abdominal surgeries : a prospective, double-blind randomized controlled study. Ain Shams Journal of Anesthesiology،Vol. 10, no. 1, pp.247-252.
https://search.emarefa.net/detail/BIM-841393
Modern Language Association (MLA)
Abd Allah, Walid& Ammar, Muna A.. Systemic granisetron can minimize hypotension and bradycardia during spinal anesthesia in patients undergoing elective lower-abdominal surgeries : a prospective, double-blind randomized controlled study. Ain Shams Journal of Anesthesiology Vol. 10, no. 1 (Mar. 2017), pp.247-252.
https://search.emarefa.net/detail/BIM-841393
American Medical Association (AMA)
Abd Allah, Walid& Ammar, Muna A.. Systemic granisetron can minimize hypotension and bradycardia during spinal anesthesia in patients undergoing elective lower-abdominal surgeries : a prospective, double-blind randomized controlled study. Ain Shams Journal of Anesthesiology. 2017. Vol. 10, no. 1, pp.247-252.
https://search.emarefa.net/detail/BIM-841393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 252
Record ID
BIM-841393