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Secondary adrenal insufficiency due to the co-administration of ritonavir and inhaled fluticasone propionate : case report
Other Title(s)
قصور كظر ثانوي نتيجة إعطاء دواء الريتونافز مع بخاخ فلوتيكاسون بروبيونات : تقرير حالة
Joint Authors
al-Qassabi, Salim
Kamble, Bina
al-Jalib, Ali
al-Maqbali, Ali
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 17, Issue 3 (31 Aug. 2017), pp.339-342, 4 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2017-08-31
Country of Publication
Oman
No. of Pages
4
Main Subjects
Abstract EN
Ritonavir is a powerful inhibitor of the cytochrome P450 3A4 (CYP3A4) isoenzyme.
It is used as a pharmaceutical enhancer in the management of HIV-positive patients.
However, when co-administered with other drugs that are metabolised via the CYP3A4 pathway, ritonavir can potentially cause serious drug-drug interactions.
Inhaled fluticasone propionate, which is used to treat asthma and chronic obstructive airway disease, is particularly prone to such interactions due to its physiological attributes.
We report a HIV-positive 48-year-old male patient who presented to Al Nahdha Hospital, Muscat, Oman, in 2012 with weight loss, generalised weakness and fatigue and diagnosed with secondary adrenal insufficiency as a result of concomitant ritonavir and inhaled fluticasone.
American Psychological Association (APA)
al-Maqbali, Ali& Kamble, Bina& al-Qassabi, Salim& al-Jalib, Ali. 2017. Secondary adrenal insufficiency due to the co-administration of ritonavir and inhaled fluticasone propionate : case report. Sultan Qaboos University Medical Journal،Vol. 17, no. 3, pp.339-342.
https://search.emarefa.net/detail/BIM-842304
Modern Language Association (MLA)
al-Maqbali, Ali…[et al.]. Secondary adrenal insufficiency due to the co-administration of ritonavir and inhaled fluticasone propionate : case report. Sultan Qaboos University Medical Journal Vol. 17, no. 3 (Aug. 2017), pp.339-342.
https://search.emarefa.net/detail/BIM-842304
American Medical Association (AMA)
al-Maqbali, Ali& Kamble, Bina& al-Qassabi, Salim& al-Jalib, Ali. Secondary adrenal insufficiency due to the co-administration of ritonavir and inhaled fluticasone propionate : case report. Sultan Qaboos University Medical Journal. 2017. Vol. 17, no. 3, pp.339-342.
https://search.emarefa.net/detail/BIM-842304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 341-342
Record ID
BIM-842304