Histological study effects of paracetamol on livers and kidneys of adult mice
Other Title(s)
دراسة نسيجية لتأثيرات البراسيتامول على الأكباد و الكلى في الفئران البالغة
Joint Authors
Abd Allah, Buthaynah Abd al-Hamid
Sarhat, Intizar Rifat
Wadi, Siham Ajami
Source
Publisher
Tikrit University College of Agriculture
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
English Abstract
Background: paracetamol is an atypical opioid with monoamine re-uptake inhibition properties.
Aim of work: This study was examined the histological changes in liver and kidney after administration of paracetamol-induced mice .Materials and methods: The study was conducted on 10 adult male mice.
Mice were divided evenly into two groups: control group, received 1 ml normal saline 0.9% Treated group received ( 0.5 )ml of paracetamol/ body weight intra-peritoneally for 30 days.
Results: The histological analysis of the liver showed that the thickening wall with minimal fibrosis in the periportal area infiltration of inflammatory cells in necrotic change of the hepatocytes massive vacoulation of the hepatocyte, kupffer cell were present intensity in the sinusoid.
The histopathological examination of kidney revealed lymphocyte infiltration , congestion ,glomerulus and tubular damage.
The tubular was containing hypertrophied epithelial cell which block the lumen .
Conclusion: The histopathological alterations of liver, and kidney tissues threw lights on the possible risks of increased hepatic, renal and neurological damages evoked by repeated administration of paracetamol for long periods.
Data Type
Conference Papers
Record ID
BIM-843578
American Psychological Association (APA)
Abd Allah, Buthaynah Abd al-Hamid& Wadi, Siham Ajami& Sarhat, Intizar Rifat. 2017-12-31. Histological study effects of paracetamol on livers and kidneys of adult mice. . Special issue (2017), pp.97-103.Salah al-Din Iraq : Tikrit University College of Agriculture.
https://search.emarefa.net/detail/BIM-843578
Modern Language Association (MLA)
Abd Allah, Buthaynah Abd al-Hamid…[et al.]. Histological study effects of paracetamol on livers and kidneys of adult mice. . Salah al-Din Iraq : Tikrit University College of Agriculture. 2017-12-31.
https://search.emarefa.net/detail/BIM-843578
American Medical Association (AMA)
Abd Allah, Buthaynah Abd al-Hamid& Wadi, Siham Ajami& Sarhat, Intizar Rifat. Histological study effects of paracetamol on livers and kidneys of adult mice. .
https://search.emarefa.net/detail/BIM-843578