Cytogenetic study on some common bone tumours
Other Title(s)
دراسة وراثية خلوية لبعض أورام العظام الشائعة في الإنسان
Joint Authors
Kazim, Wafa Abd al-Amir
al-Rikabi, Nahi Yusuf Yasin
al-Jabburi, Khalil Hasan Zinad
Source
Iraqi Journal of Cancer and Medical Genetics
Issue
Vol. 10, Issue 1 (30 Jun. 2017), pp.26-32, 7 p.
Publisher
al-Mustansyriah University Iraqi Centre for Cancer and Medical Genetics Research
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
This study aimed to detect the consistent chromosomal abnormalities of each type of common bone tumours .
Thirty bone tumors specimens were processed for direct cytogenetic preparation , only (9 cases) showed success results for chromosomal preparation by banding technique , the results of cytogenetic study were 1- Osteosarcoma (4) cases revealed multiple numerical and structural changes with complex karyotype and pronounced cell to cell variation .
chromosome 17 was the most frequent involved in these chromosomal alteration .
Also loss or structural changes of chromosome 13 was found in (2) cases of osteosarcoma loss or gain of sex chromosome were detected in these cases , loss of Y chromosome in (2) cases ; loss of X chrosome in (1) case and gain of X chrosome in another case .
2- Osteochnodroma : reveled the simple numerical change with no structural change in one case .
3- Chondroblastoma : in this tumor structural and numerical abnormalities of chrosome 5 .
4- Chondrosarcoma : showed chromosomal aberration with multiple numerical and structural changes in chromosome (1) was of interest and monsomy 18 was reported in one case .
5- Giant cell tumors : It showed a complex changes and the range of chromosomal number was 50 – 58 with the characteristic telomeric fusion in malignant cases while simple numerical change only in benign giant cell tumor .
Conclusion Cytogenetic study of both benign and malignant bone tumors have revealed abnormlities in the number and / or structures of chromosomes X, Y , 1,5,6,11 , 13,17,18 and complex chromosomal changes in malignant types of bone tumors .
American Psychological Association (APA)
al-Rikabi, Nahi Yusuf Yasin& al-Jabburi, Khalil Hasan Zinad& Kazim, Wafa Abd al-Amir. 2017. Cytogenetic study on some common bone tumours. Iraqi Journal of Cancer and Medical Genetics،Vol. 10, no. 1, pp.26-32.
https://search.emarefa.net/detail/BIM-844619
Modern Language Association (MLA)
al-Rikabi, Nahi Yusuf Yasin…[et al.]. Cytogenetic study on some common bone tumours. Iraqi Journal of Cancer and Medical Genetics Vol. 10, no. 1 (2017), pp.26-32.
https://search.emarefa.net/detail/BIM-844619
American Medical Association (AMA)
al-Rikabi, Nahi Yusuf Yasin& al-Jabburi, Khalil Hasan Zinad& Kazim, Wafa Abd al-Amir. Cytogenetic study on some common bone tumours. Iraqi Journal of Cancer and Medical Genetics. 2017. Vol. 10, no. 1, pp.26-32.
https://search.emarefa.net/detail/BIM-844619
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-844619