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Comparison of some salivary biomarkers between luminal and triple negative subtypes after surgical removal of invasive ductal carcinoma
Other Title(s)
مقارنة بعض المؤشرات الحيوية اللعابية ما بين النمط اللمعي و النمط السلبي الثلاثي للسرطان القنوي الاجتياحي بعد الإزالة الجراحية
Author
Source
Iraqi Journal of Cancer and Medical Genetics
Issue
Vol. 10, Issue 1 (30 Jun. 2017), pp.48-55, 8 p.
Publisher
al-Mustansyriah University Iraqi Centre for Cancer and Medical Genetics Research
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Luminal (L) and triple negative (TN) subtypes of breast cancer (BC) are recorded in Iraqi women which have different incidence, treatment, progression, and metastases.
This study is aimed to compare some risk factors and salivary biomarkers between them.
Only premenopausal Iraqi women with invasive ductal carcinoma (IDC) are involved in this study.
Based on histopathologic and immunohistochemistry (IHC) report carried out by hospital itself, the age, Subtype and grade of tumor were recorded, while waist/hip ratio, secretory status, and salivary levels of Ca 15-3, total protein (TP), and PH were determined 2-3 weeks after surgery and before starting therapy.
Results revealed that luminal is the predominant subtype of IDC and constitute about 80.5% and the rest (19.5%) is TN subtype, however HER-2 subtype didn’t recorded.
Also women with TN are presented at age 40.7 year which is significantly (P ˂ 0.05) lower than that in (L) subtype (47.1 year).
All TN cases are non-secretor and presented at grade 3 and their saliva is more acidic and containing higher levels of Ca 15-3, and TP than those in (L) cases.
Our results suggested that saliva can be used as an alternative diagnostic sample in differentiation between various subtypes of IDC, and secretory status of patients may be contribute in determining the subtype of BC.
American Psychological Association (APA)
Salih, Khalid Mahdi. 2017. Comparison of some salivary biomarkers between luminal and triple negative subtypes after surgical removal of invasive ductal carcinoma. Iraqi Journal of Cancer and Medical Genetics،Vol. 10, no. 1, pp.48-55.
https://search.emarefa.net/detail/BIM-844631
Modern Language Association (MLA)
Salih, Khalid Mahdi. Comparison of some salivary biomarkers between luminal and triple negative subtypes after surgical removal of invasive ductal carcinoma. Iraqi Journal of Cancer and Medical Genetics Vol. 10, no. 1 (2017), pp.48-55.
https://search.emarefa.net/detail/BIM-844631
American Medical Association (AMA)
Salih, Khalid Mahdi. Comparison of some salivary biomarkers between luminal and triple negative subtypes after surgical removal of invasive ductal carcinoma. Iraqi Journal of Cancer and Medical Genetics. 2017. Vol. 10, no. 1, pp.48-55.
https://search.emarefa.net/detail/BIM-844631
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-844631