Antimutagenic effect of grape seed extracted oil on diazinon induced genotoxicity in albino mice
Other Title(s)
التأثيرات المضادة للتطفير لمستخلص زيت بذور العنب على مبيد الديازينون في الفئران المختبرية
Author
al-Attar, Mustafa Sabir Mustafa
Source
Iraqi Journal of Cancer and Medical Genetics
Issue
Vol. 10, Issue 1 (30 Jun. 2017), pp.56-62, 7 p.
Publisher
al-Mustansyriah University Iraqi Centre for Cancer and Medical Genetics Research
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Background: Human health hazard due to exposure to chemical pollutants is a global and chronic problem.
The pesticides constitute the primary toxic chemicals in the environment.
The present study explored the effects of grape seed oil supplementation on diazinon (DZN) induced chromosomal aberrations and sperm abnormalities in male mice.
Materials and methods: The tests were carried out on 35 adult male albino mice (16-20 weeks, weighed 30-35 g).
Animals were categorized into seven groups each with five mice; the first group was treated with phos¬phate buffer saline (PBS) as negative control group.
The second and third groups were treated daily and orally with two different doses of the DZN (60 and 90 mg/kg body weight) respectively dissolved in corn oil.
Animals of fourth, fifth and sixth groups were orally administered grape seed oil at a dose of 2 g/kg body weight, after 6 hours the fourth and fifth groups subjected to DZN at the same dose given to second and third groups.
Animals of the seventh group were supplied with corn oil.
The treatments were continued for five weeks.
Results: The results showed that DZN increased the frequency of both chromatid and chromosome aberrations in bone marrow cells and sperm abnormalities.
Treatment with grape seed oil extract showed a significant decrease (P<0.01) on both total abnormal chromosomes and sperms, and there was no significant difference between these groups and negative control in most analyzed parameters.
The dose of grape seed oil has significantly minimized the effect of first dose of DZN concerning chromosome structure while it worked in the second dose regarding sperm abnormalities.
Conclusions: This finding suggests the protective action of grape seed oil against DZN induced clastogenecity and sperm abnormalities.
American Psychological Association (APA)
al-Attar, Mustafa Sabir Mustafa. 2017. Antimutagenic effect of grape seed extracted oil on diazinon induced genotoxicity in albino mice. Iraqi Journal of Cancer and Medical Genetics،Vol. 10, no. 1, pp.56-62.
https://search.emarefa.net/detail/BIM-844633
Modern Language Association (MLA)
al-Attar, Mustafa Sabir Mustafa. Antimutagenic effect of grape seed extracted oil on diazinon induced genotoxicity in albino mice. Iraqi Journal of Cancer and Medical Genetics Vol. 10, no. 1 (2017), pp.56-62.
https://search.emarefa.net/detail/BIM-844633
American Medical Association (AMA)
al-Attar, Mustafa Sabir Mustafa. Antimutagenic effect of grape seed extracted oil on diazinon induced genotoxicity in albino mice. Iraqi Journal of Cancer and Medical Genetics. 2017. Vol. 10, no. 1, pp.56-62.
https://search.emarefa.net/detail/BIM-844633
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-844633