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Nephroprotective roles of local licorice, peppermint extracts and their mixture on gentamicin-induced renal insufficiency in Wistar albino rats
Joint Authors
Ghazi, Ali M.
Abd al-Husayn, Jamilah K.
al-Baghdadi, Rana Jabir Tarish
Source
al-Qadisiyah Journal of Veterinary Medicine Sciences
Issue
Vol. 16, Issue 2 (31 Dec. 2017), pp.61-68, 8 p.
Publisher
al-Qadisiyah University College of Veterinary Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Aminoglycosides (AGs) such as gentamicin (gen) are considered as the optimum therapy for many infections and diseases.
Unfortunately, AGs treatment has been linked to acute kidney injury that is also referred to as nephrotoxicity.
In the current study, we sought to explore the protective roles of peppermint (pep) and licorice (Lic) extracts as well as their mixture on gen-induced nephrotoxicity.
Forty male and female Wistar albino rats were divided into 5 experimental groups: C- was administered with 2 ml of normal saline as a single daily dose intraperitoneally (i.p.) for 14 d.
C+ was administered with once-daily i.p.
injections of 100 mg/kg BW gen for 8 d.
T1 group was administered once-daily i.p.
of gen (100mg/kg BW) for 8 d.
and Lic ethanolic extract (EE) (100mg/kg BW) every 12 hr for 14 d.
T2 was administered once-daily i.p.
of gen for 8 d.
and pep EE (100mg/kg BW) every 12 hr for 14 d.
T3 was administered once-daily i.p.
of gen for 8 d.
in addition to lic and pep EE mixture (100mg/kg BW) every 12 hr for 14 d.
At the end of the study, all rats were anesthetized and trunk blood collected to study renal injury parameters.
Those include serum enzymes such as AST, ALT, and ALP; kidney damage markers including urea, creatinine, and total protein; serum electrolytes including Cl, K, and Na levels as well as other renal function markers such as Glutathione peroxidase (GSH) and superoxide dismutase (SOD).
All the parameters that indicated the nephrotoxicity occurrence in the C+ group in response to gen were found to be highly improved in most of the studied aspects in T1, T2, and T3.
We found that Lic and pep extracts improve renal injury, kidney damage, and renal function markers opposed to gentamicin treatment.
In conclusion, our study suggests prescribing those remedies to AGs receiving patients.
American Psychological Association (APA)
al-Baghdadi, Rana Jabir Tarish& Ghazi, Ali M.& Abd al-Husayn, Jamilah K.. 2017. Nephroprotective roles of local licorice, peppermint extracts and their mixture on gentamicin-induced renal insufficiency in Wistar albino rats. al-Qadisiyah Journal of Veterinary Medicine Sciences،Vol. 16, no. 2, pp.61-68.
https://search.emarefa.net/detail/BIM-847111
Modern Language Association (MLA)
al-Baghdadi, Rana Jabir Tarish…[et al.]. Nephroprotective roles of local licorice, peppermint extracts and their mixture on gentamicin-induced renal insufficiency in Wistar albino rats. al-Qadisiyah Journal of Veterinary Medicine Sciences Vol. 16, no. 2 (2017), pp.61-68.
https://search.emarefa.net/detail/BIM-847111
American Medical Association (AMA)
al-Baghdadi, Rana Jabir Tarish& Ghazi, Ali M.& Abd al-Husayn, Jamilah K.. Nephroprotective roles of local licorice, peppermint extracts and their mixture on gentamicin-induced renal insufficiency in Wistar albino rats. al-Qadisiyah Journal of Veterinary Medicine Sciences. 2017. Vol. 16, no. 2, pp.61-68.
https://search.emarefa.net/detail/BIM-847111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 67-68
Record ID
BIM-847111