The congenital malformations in white pregnant mice fetus induced by metformin drug during 6-18 days of gestation

Joint Authors

Tumah, Faizah Nasir
Hamid, Aziz Khalid
Jamil, Ismat Jamal

Source

مجلة ابن الهيثم للعلوم الصرفة و التطبيقية

Publisher

University of Baghdad College of Education for Pure Science / Ibn al-Haitham

Publication Date

2017-12-31

Country of Publication

Iraq

No. of Pages

11

Main Subjects

Arts

English Abstract

The metformin drug is anti-hyperglycemia and known to cross the placenta which leads to the fetus during pregnancy.

The aim of this study is to define the drug effects in the fetus growth.

The doses used, therapeutic dose (0.18 & 0.53) mg\25g body weight and over dose (1.8 & 2.85) mg\ 25g body weight, administrated orally at the beginning organogenesis stage at (6 -18) day of pregnancy in the morning.

A total (50) animal were divided into five groups.

The first group control not treated, 2nd group treated with (0.18) mg, 3rd group with (0.53) mg , 4th group with ( 1.8 ) mg and 5th group with ( 2.85 ) mg .

In this study noted some congenital malformations in the fetus compared with normal control group , which included in the 2nd and 3rd group ( irregular body level , exophthalmia , micromelia , elevated some hand fingers , simple club foot , torsion tail and wrinkle skin ) while the defects was larger in the 4th and 5th group ( trunk abnormalities like C Shape , big head ( scaphocethaly) , cranial flexure , prosencephaly, short neck , micromelia , syndactyly some of hand fingers and others hemimelia , torsion tail and some aquiline , sharply club foot and spina bifida ) .

It is mentioning that the malformations were less in the 2nd group treated with (0.18) mg of the drug.

The treatment with metformin drug during pregnancy induced the congenital malformations.

Data Type

Conference Papers

Record ID

BIM-851535

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