The FSHR polymorphisms association with polycystic ovary syndrome in women of Erbil, Kurdistan in north of Iraq
Joint Authors
Baban, Aishah Sh. Sh.
Khurshid, Sabah H.
al-Hayawi, Anas Y.
Source
مجلة ابن الهيثم للعلوم الصرفة و التطبيقية
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
English Abstract
Polycystic ovary syndrome (PCOS) is an endocrine disorder in women during fertilization age that reflects changing clinical symptoms.
The genetic concept of PCOS is unclear and no significant genetic association with PCOS has been established.
The level of Follicle stimulating hormone FSH is encoded by FSH receptor (FSHR) and abnormal FSHR affects follicle cogenesis and ovary and consist of 9 introns, 10 exons, and the region of chromosome promoter at 2p21.
Sample of 93PCOS patients and 52 controls were collected from Province of Erbil in north of Iraq.
Genomic DNA was extracted from the blood and genotype dissected was improved for the two population of study using PCR-RFLP with the restriction enzyme Eam1105I.
The genotype distributions and allele frequency of Ala307Thr polymorphisms of FSHR were not statistically various between the controls and the PCOS patients.
Significant elevation of body mass index with all genotype of PCOS was found when compared with controls.
There were statistical differences in the BMI and most of the serum hormone and lipid profile parameters including LH, total testosterone, fasting glucose, Cholesterol, HDL and LDL, there were significant various in FSH and LH levels of hormones and HDL, LDL and VLDL with PCOS group conveying different genotypes of Ala307Thr polymorphisms.
The variant of Ala307Thr was not associated with PCOS in Kurdistan women; there was no relationship between the POCS and gene of FSHR polymorphism at codons 307.
There was a significant difference in FSH and LH levels with PCOS patients conveying different genotypes of Ala307Thr polymorphism
Data Type
Conference Papers
Record ID
BIM-851589
American Psychological Association (APA)
Baban, Aishah Sh. Sh.& Khurshid, Sabah H.& al-Hayawi, Anas Y.. 2017-12-31. The FSHR polymorphisms association with polycystic ovary syndrome in women of Erbil, Kurdistan in north of Iraq. International Conference on Biology, Chemistry, Computer Science, Mathematics, and Physics, will take place (2017 : Ibn Al Haitham University of Baghdad, Iraq). . Special issue (2017).Baghdad Iraq : University of Baghdad College of Education for Pure Science / Ibn al-Haitham.
https://search.emarefa.net/detail/BIM-851589
Modern Language Association (MLA)
Baban, Aishah Sh. Sh.…[et al.]. The FSHR polymorphisms association with polycystic ovary syndrome in women of Erbil, Kurdistan in north of Iraq. . Baghdad Iraq : University of Baghdad College of Education for Pure Science / Ibn al-Haitham. 2017-12-31.
https://search.emarefa.net/detail/BIM-851589
American Medical Association (AMA)
Baban, Aishah Sh. Sh.& Khurshid, Sabah H.& al-Hayawi, Anas Y.. The FSHR polymorphisms association with polycystic ovary syndrome in women of Erbil, Kurdistan in north of Iraq. . International Conference on Biology, Chemistry, Computer Science, Mathematics, and Physics, will take place (2017 : Ibn Al Haitham University of Baghdad, Iraq).
https://search.emarefa.net/detail/BIM-851589
