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Nano-particle engineered atorvastatin delivery to support mesenchymal stem cell survival in infarcted myocardium
Joint Authors
Wang, Jin
Yao, Guangtao
Song, Li Ping
Xue, Wan Hua
Su, Guo Hai
Ning, Ai Hua
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 6 (30 Sep. 2018), pp.1016-1021, 6 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Atorvastatin (ATV) may support mesenchymal stem cells (MSC) survival in post-infarct myocardium (MI) as inflammatory reactions, oxidative stress and hypoxia condition get started in such tissues after damage.
However, limited aqueous insolubility and rapid first-pass metabolism reduce the systemic availability of ATV.
The aim of the present investigation was to develop ATV loaded nanoparticles (ATVNPs) which might ensure the maximum availability of ATV in systemic circulation for longer duration and to strengthen the support to MSC survival.
ATVNPs were synthesized using double emulsion solvent evaporation method and characterized as spherical shape, positive charged, nanoparticles of uniform size distribution and higher entrapment efficiency.
ATVNPs were non-cytotoxic and showed sustained release (up to 28 days).
Assessment of cardiac function (in terms of echocardiographic and left heart catheterization parameters) and cytokines estimation revealed efficient improvement in post-infarct myocardium condition of rat.
In conclusion, ATVNP was developed successfully that may ensure safe, cost effective, and efficacious treatment of post-infarct myo-cardium when compared with that of MSC alone and MSC supplemented with ATV solution
American Psychological Association (APA)
Yao, Guangtao& Song, Li Ping& Xue, Wan Hua& Su, Guo Hai& Ning, Ai Hua& Wang, Jin. 2018. Nano-particle engineered atorvastatin delivery to support mesenchymal stem cell survival in infarcted myocardium. Saudi Journal of Biological Sciences،Vol. 25, no. 6, pp.1016-1021.
https://search.emarefa.net/detail/BIM-851797
Modern Language Association (MLA)
Yao, Guangtao…[et al.]. Nano-particle engineered atorvastatin delivery to support mesenchymal stem cell survival in infarcted myocardium. Saudi Journal of Biological Sciences Vol. 25, no. 6 (Sep. 2018), pp.1016-1021.
https://search.emarefa.net/detail/BIM-851797
American Medical Association (AMA)
Yao, Guangtao& Song, Li Ping& Xue, Wan Hua& Su, Guo Hai& Ning, Ai Hua& Wang, Jin. Nano-particle engineered atorvastatin delivery to support mesenchymal stem cell survival in infarcted myocardium. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 6, pp.1016-1021.
https://search.emarefa.net/detail/BIM-851797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1021
Record ID
BIM-851797