The naturally occurring xanthone a-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells

Abstract EN

Small cell lung cancer (NSCLC) accounts for 85% of total deaths globally, and recent studies indicate the increasing risks of NSCLC in China and South Asian countries.

Hence, development of new therapeutics against NSCLC has been a major concern.

a-Mangostin, a naturally occurring xanthone, found abundantly in pericarps of mangosteen fruit is well known for its medicinal importance.

The anticancer properties of a-mangostin against several types of cancer are also well documented.

But the mechanism of action of a-mangostin against lung cancer is not well understood and requires further investigation.

Therefore in the present study, we explored the therapeutic potential of a-mangostin against A549 cells.

Treatment of A549 cells with a-mangostin resulted in a dose-dependent loss of cell viability, while the non-malignant cells such as hPBMC and WI-38 remained unaffected.

Further we observed that the ROS plays an important role in a-mangostin -induced apoptosis in A549 cells, and administration of N-acetyl cysteine significantly abrogates a-mangostin -mediated cytotoxicity in lung cancer cells.

Overall, a-mangostin induces ROS-mediated cytotoxicity in NSCLC cells