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Effects of a medicinal plant Macrotyloma uniflorum (Lam.) Verdc.formulation (MUF) on obesity-associated oxidative stress-induced liver injury
Joint Authors
Abd Allah, al-Sayyid Fathi
Hashim, Abir
al-Qarawi, Abd al-Aziz Abd Allah
Radhakrishnan, Ramalingam
Bharathi, Vadivelu
Rengarajan, R. L.
Anand, Arumugam Vijaya
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 6 (30 Sep. 2018), pp.1115-1121, 7 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Obesity is a global health burden due to lifestyle modifications that have a strong association with a high incidence of diseases, such as dyslipidemia, glucose intolerance, nonalcoholic fatty liver diseases, diabetes, hypertension, coronary heart disease and cancer.
The aim of the present study is to investigate the protective effects of a Macrotyloma uniflurom formulation (MUF) against high-fat diet (HFD)- induced oxidative stress and inflammation in obese rats.
Male albino Wistar rats were fed a high-fat diet for 6 weeks to facilitate fat-induced oxidative stress and were simultaneously treated with MUF (400 mg/ kg b.w.) through oral gavage from the third week onwards during the treatment phase.
At the end of the experimental period, hepatic and oxidative stress markers were examined.
The mRNA expression levels of inflammatory marker genes [Tumor Necrosis Factor-a (TNF-a) and Interleukin-6 (IL-6)] were also determined by reverse transcriptase-polymerase chain reaction in liver tissue.
Hepatic marker enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transferase) and lipid peroxidation markers (Thiobarbituric acid reactive substances and LOOH) were significantly increased in HFD-fed rats, and administration of MUF resulted in remarkable suppression of these markers.
Administration of MUF to HFD rats enhanced the activity of enzymatic (superoxide dismutase, catalase and glutathione peroxidase and non-enzymatic (vitamin E, vitamin C and glutathione) antioxidants compared to HFD-fed rats.
An anti-inflammatory effect of MUF was demonstrated by attenuating gene expression of TNF-a and IL-6.
Therefore, the results of this study indicate that MUF could be a strong herbal therapeutic alternative for the protection of the liver as well as prevention and treatment of highfat-induced oxidative stress and inflammation.
American Psychological Association (APA)
Bharathi, Vadivelu& Rengarajan, R. L.& Radhakrishnan, Ramalingam& Hashim, Abir& Abd Allah, al-Sayyid Fathi& al-Qarawi, Abd al-Aziz Abd Allah…[et al.]. 2018. Effects of a medicinal plant Macrotyloma uniflorum (Lam.) Verdc.formulation (MUF) on obesity-associated oxidative stress-induced liver injury. Saudi Journal of Biological Sciences،Vol. 25, no. 6, pp.1115-1121.
https://search.emarefa.net/detail/BIM-851829
Modern Language Association (MLA)
Bharathi, Vadivelu…[et al.]. Effects of a medicinal plant Macrotyloma uniflorum (Lam.) Verdc.formulation (MUF) on obesity-associated oxidative stress-induced liver injury. Saudi Journal of Biological Sciences Vol. 25, no. 6 (Sep. 2018), pp.1115-1121.
https://search.emarefa.net/detail/BIM-851829
American Medical Association (AMA)
Bharathi, Vadivelu& Rengarajan, R. L.& Radhakrishnan, Ramalingam& Hashim, Abir& Abd Allah, al-Sayyid Fathi& al-Qarawi, Abd al-Aziz Abd Allah…[et al.]. Effects of a medicinal plant Macrotyloma uniflorum (Lam.) Verdc.formulation (MUF) on obesity-associated oxidative stress-induced liver injury. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 6, pp.1115-1121.
https://search.emarefa.net/detail/BIM-851829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1121
Record ID
BIM-851829