Ifosfamide-loaded lipid-core-nanocapsules to increase the anticancer efficacy in MG63 osteosarcoma cells
Joint Authors
Wang, Sheng Qun
Zhang, Qiao
Liu, Guang Yao
Sun, Chao
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 6 (30 Sep. 2018), pp.1140-1145, 6 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
In this study, we mainly aimed at developing the Ifosfamide-loaded-lipid-core nanocapsules (IFS-LNC) to increase the therapeutic efficacy in osteosarcoma.
The nanoparticle was prepared and evaluated in terms of physical, chemical and biological parameters.
The lipid-corenanocapsules were nanosized with narrow particle size distribution and exhibited a high loading capacity.
The LNC displayed a sustained release profile of the drug suggesting its potential application in biomedical field and prolonged anticancer therapy.
The LNC showed an endocytosismediated cellular uptake in MG63 cancer cells which may lead to an accelerated disruption of the acidic endolysosomal vesicles with release of IFS into the cytoplasm.
Specifically, IFS-LNC exhibited a significantly higher cytotoxicity than free IFS used at the same concentration.
The indiscriminate ability of the drug-loaded formulation increased the apoptosis of cancer cells by increasing the expression levels of caspase-3 and caspase-9 in MG63 cells.
Overall, nanoparticulate formulations of Ifosfamide enhanced the therapeutic efficacy in osteosarcoma
American Psychological Association (APA)
Wang, Sheng Qun& Zhang, Qiao& Sun, Chao& Liu, Guang Yao. 2018. Ifosfamide-loaded lipid-core-nanocapsules to increase the anticancer efficacy in MG63 osteosarcoma cells. Saudi Journal of Biological Sciences،Vol. 25, no. 6, pp.1140-1145.
https://search.emarefa.net/detail/BIM-851857
Modern Language Association (MLA)
Wang, Sheng Qun…[et al.]. Ifosfamide-loaded lipid-core-nanocapsules to increase the anticancer efficacy in MG63 osteosarcoma cells. Saudi Journal of Biological Sciences Vol. 25, no. 6 (Sep. 2018), pp.1140-1145.
https://search.emarefa.net/detail/BIM-851857
American Medical Association (AMA)
Wang, Sheng Qun& Zhang, Qiao& Sun, Chao& Liu, Guang Yao. Ifosfamide-loaded lipid-core-nanocapsules to increase the anticancer efficacy in MG63 osteosarcoma cells. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 6, pp.1140-1145.
https://search.emarefa.net/detail/BIM-851857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1144-1145
Record ID
BIM-851857