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Embryotoxicity and teratogenicity of fipronil in rats (rattus norvegicus)
Other Title(s)
التأثيرات التشوهية الجنينية لمبيد الفيبرونيل على الجرذان البيضاء (Rattus norvegicus)
Joint Authors
Isa, Amal Abd al-Aziz
Abu al-Gar, Jamal al-Sayyid
Ammar, Ibrahim Mahmud
Mutawalli, Halah Jabr
Arafah, Samah Said
Source
Zagazig Journal for Agricultural Researches
Issue
Vol. 44, Issue 5 (31 Oct. 2017), pp.1851-1862, 12 p.
Publisher
Zagazig University Faculty of Agriculture
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Teratogenic and embryotoxic effects of fipronil insecticide were studied following orally intubation of pregnant female rats.
The animals were treated with different doses ١/١٠ LD٥٠ (٢.١ mg/kg b.wt) and ١/٣٠ LD٥٠ (٠.٧ mg/kg b.wt) at the ٦th to ١٥th days of pregnancy (time of organogenesis).
At the ٢٠th days of pregnancy, pregnant females were subjected to a caesarean section.
The effect of the fipronil on fetal development was evaluated.
Maternal weight gain decreased at ١/١٠ and ١/٣٠ LD٥٠ of fipronil.
The body weight and length of viable fetuses significantly decreased with both tested doses.
Visceral examination revealed cleft palate, heart and lungs hypoplasia, liver and kidneys atrophy increased with fipronil treatments at different doses.
Skeletal examination showed incomplete ossification of the skull bones, short ribs, coccygeal absences, sternbrae abscence and digits of fore and hind limbs.
American Psychological Association (APA)
Isa, Amal Abd al-Aziz& Abu al-Gar, Jamal al-Sayyid& Ammar, Ibrahim Mahmud& Mutawalli, Halah Jabr& Arafah, Samah Said. 2017. Embryotoxicity and teratogenicity of fipronil in rats (rattus norvegicus). Zagazig Journal for Agricultural Researches،Vol. 44, no. 5, pp.1851-1862.
https://search.emarefa.net/detail/BIM-851905
Modern Language Association (MLA)
Isa, Amal Abd al-Aziz…[et al.]. Embryotoxicity and teratogenicity of fipronil in rats (rattus norvegicus). Zagazig Journal for Agricultural Researches Vol. 44, no. 5 (2017), pp.1851-1862.
https://search.emarefa.net/detail/BIM-851905
American Medical Association (AMA)
Isa, Amal Abd al-Aziz& Abu al-Gar, Jamal al-Sayyid& Ammar, Ibrahim Mahmud& Mutawalli, Halah Jabr& Arafah, Samah Said. Embryotoxicity and teratogenicity of fipronil in rats (rattus norvegicus). Zagazig Journal for Agricultural Researches. 2017. Vol. 44, no. 5, pp.1851-1862.
https://search.emarefa.net/detail/BIM-851905
Data Type
Journal Articles
Language
English
Record ID
BIM-851905