Synthesis, characterization and biological evaluation of new dithiocarbainate ligand and its complexes with some metal ions

Abstract EN

New bidentate dithiocarbaimate ligand (NaL) namely [Sodinm-2-(((3-methyl -4- (2,2,2-tri fluoro ethoxy) pyridin-2 -yl) methyl) snlfinyl)-lH-benzoimidazole -1-carbodithioate] was prepared.

Tliis free ligand was synthesized from the reaction of a (RS)-2-([3-methyl -4-(2T2,2-in fluoroethoxy) pyndm-2-yl] methyl sulfin>i)-lH benzoimidazole.

CS2 and NaOH in methanol as solvent.

From reaction of dithiocarbaimate salt (NaL) with metal ions (M); Co(II).

Ni(II).

Cu(II).

Zn(II).

Cd(H) and Pd(II) .

have obtained the DTC complexes at general molecular formula [M(L)2(H20)2] and [Pd(L)2].

To characterize the ligand and its complexes, used different analyses methods such FTIR.

UV-Vis.

elemental microanalysis, atomic absoreption.

magnetic susceptibility, conductance, melting points.

1H- 13C- NMR spectroscopy, thermal analysis and mass spectrum.

These studies indicated the formation of DTC complexes which their geometries about metal centers are octahedral; except Pd-complex is square planer.

The acterial activity evaluation against investigated bacterial species indicated that the metal complexes are more active than the free ligand when compared them.