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Polysaccharide isolated from seeds of Plantago asiatica L. induces maturation of dendritic cells through MAPK and NF-kB pathway
Joint Authors
Jiang, Leming
Huang, Danfei
Xie, Mingyong
Nie, Shaoping
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 6 (30 Sep. 2018), pp.1202-1207, 6 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
Plantago species are used as traditional medicine in Asian and Europe.
Polysaccharide isolated from the seeds of Plantago asiatica L.
could stimulate maturation transformation of bone-marrow derived dendritic cells (DCs).
We found that blocking p38, ERK1/2 and JNK MAPK signal transduction could significantly decreased the PLP-2 induced expression of MHC II, CD86 surface molecules on DCs.
Blocking p38 and JNK signal also significantly inhibited the cytokine secretion of TNF-α and IL-12p70 as well, while blocking ERK1/2 signal only decreased the secretion of TNF-α.
Meanwhile, DCs in the three MAPK signal-blocking groups showed dramatically attenuated effects on stimulating proliferation of T lymphocytes.
Similarly, blocking signal transduction of NF-κB pathway also significantly impaired the phenotypic and functional maturation development of DCs induced by PLP-2.
These data suggest that MAPK and NF-κB pathway mediates the PLP-induced maturation on DCs.
Especially, among the three MAPK pathways, activation of JNK signal transduction is the most important for DCs development after PLP-2 incubation.
And PLP-2 may activate the MAPK and NF-κB pathway by triggering toll-like receptor 4 on DCs.
American Psychological Association (APA)
Jiang, Leming& Huang, Danfei& Nie, Shaoping& Xie, Mingyong. 2018. Polysaccharide isolated from seeds of Plantago asiatica L. induces maturation of dendritic cells through MAPK and NF-kB pathway. Saudi Journal of Biological Sciences،Vol. 25, no. 6, pp.1202-1207.
https://search.emarefa.net/detail/BIM-852207
Modern Language Association (MLA)
Jiang, Leming…[et al.]. Polysaccharide isolated from seeds of Plantago asiatica L. induces maturation of dendritic cells through MAPK and NF-kB pathway. Saudi Journal of Biological Sciences Vol. 25, no. 6 (Sep. 2018), pp.1202-1207.
https://search.emarefa.net/detail/BIM-852207
American Medical Association (AMA)
Jiang, Leming& Huang, Danfei& Nie, Shaoping& Xie, Mingyong. Polysaccharide isolated from seeds of Plantago asiatica L. induces maturation of dendritic cells through MAPK and NF-kB pathway. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 6, pp.1202-1207.
https://search.emarefa.net/detail/BIM-852207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1207
Record ID
BIM-852207