Genome-wide hypomethylation of LINE-1 and Alu retroelements in cellfree DNA of blood is an epigenetic biomarker of human aging
Joint Authors
Dakhil, Muhammad A.
Hafiz, Taghrid A.
Erichsen, Lars
Beermann, Agnes
Arauzo Bravo, Marcos J.
Fischer, Johannes C.
Santourlidis, Simeon
Hasan, Muhammad al-Sayyid
al-Qurayshi, Salih
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 6 (30 Sep. 2018), pp.1220-1226, 7 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Aging associated DNA hypomethylation of LINE-1 and Alu retroelements may be a crucial determinant of loss of genomic integrity, deterioration and cancer.
In peripheral blood LINE-1 hypomethylation has been reported to increase during aging, but other studies did not observe significant changes.
We hypothesized that these apparently inconsistent reports might relate to differences between cellular and cell-free DNA.
Using the technique of idiolocal normalization of real-time methylation-specific PCR (IDLN-MSP) for genetic imbalanced DNA specimens we obtained evidence that LINE-1 hypomethylation in cell-free DNA, but not cellular DNA from peripheral blood is an epigenetic biomarker for human aging.
Furthermore, hypomethylation of cell-free DNA is more extensive in smokers, suggesting that it might be used as a surrogate marker for monitoring the improvement of smoking-induced adverse effects after cancelling smoking
American Psychological Association (APA)
Erichsen, Lars& Beermann, Agnes& Arauzo Bravo, Marcos J.& Dakhil, Muhammad A.& al-Qurayshi, Salih& Hafiz, Taghrid A.…[et al.]. 2018. Genome-wide hypomethylation of LINE-1 and Alu retroelements in cellfree DNA of blood is an epigenetic biomarker of human aging. Saudi Journal of Biological Sciences،Vol. 25, no. 6, pp.1220-1226.
https://search.emarefa.net/detail/BIM-852210
Modern Language Association (MLA)
al-Qurayshi, Salih…[et al.]. Genome-wide hypomethylation of LINE-1 and Alu retroelements in cellfree DNA of blood is an epigenetic biomarker of human aging. Saudi Journal of Biological Sciences Vol. 25, no. 6 (Sep. 2018), pp.1220-1226.
https://search.emarefa.net/detail/BIM-852210
American Medical Association (AMA)
Erichsen, Lars& Beermann, Agnes& Arauzo Bravo, Marcos J.& Dakhil, Muhammad A.& al-Qurayshi, Salih& Hafiz, Taghrid A.…[et al.]. Genome-wide hypomethylation of LINE-1 and Alu retroelements in cellfree DNA of blood is an epigenetic biomarker of human aging. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 6, pp.1220-1226.
https://search.emarefa.net/detail/BIM-852210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1225-1226
Record ID
BIM-852210