Correlation of the homeostasis model assessment index and adiponectin, leptin and insulin levels to body mass index-associated gene polymorphisms in adolescents
Other Title(s)
العلاقة بين منسب تقييم نموذج الاستباب و مستويات الأديبونيكتن و اللبتين و الأنسولين و منسب كتلة الجسم المرتبط بتعدد الأشكال الجينية عند المراهقين
Joint Authors
Martinez, Maria D. Martinez
Celis, Luis
Layton Tovar, Cristian F.
Torres Garcia, Rocio
Gutierrez Pliego, Laura E.
Camarillo Romero, Eneida
Garduno Garcia, Jose D.
Camarillo Romero, Maria D.
Mendieta Zeron, Hugo
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 18, Issue 3 (31 Aug. 2018), pp.291-298, 8 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2018-08-31
Country of Publication
Oman
No. of Pages
8
Main Subjects
Abstract EN
Objectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesityassociated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801282 single nucleotide polymorphisms (SNPs) as indicators of body mass index in adolescents.
Methods: This cross-sectional study was conducted between September and December 2016 in Toluca, Mexico.
A total of 71 students between 14–18 years old were included.
Various anthropometric and laboratory measurements were collected, including lipid profile, glucose, insulin and adipokine levels and HOMA index.
The degree of association between variables was evaluated with regards to the presence/absence of the SNPs.
Results: Leptin levels were significantly higher among female students (P = 0.001), although adiponectin levels did not differ significantly (P = 0.060).
There were significant positive correlations between insulin levels and HOMA index with FTO (r = 0.391; P = 0.007 and r = 0.413; P = 0.005, respectively) and PPARγ (r = 0.529; P = 0.007 and r = 0.537; P = 0.007, respectively) SNPs.
Leptin showed a significant positive correlation in the presence of PPARγ (r = 0.483; P = 0.007) or in the absence of both SNPs (r = 0.627; P = 0.039).
However, adiponectin was significantly negatively correlated in the presence of FTO, either alone (r = −0.333; P = 0.024) or in combination with PPARγ (r = −0.616; P = 0.043).
Conclusion: The presence of FTO and/or PPARγ SNPs might be related to a genetic predisposition to metabolic syndrome.
American Psychological Association (APA)
Martinez, Maria D. Martinez& Mendieta Zeron, Hugo& Celis, Luis& Layton Tovar, Cristian F.& Torres Garcia, Rocio& Gutierrez Pliego, Laura E.…[et al.]. 2018. Correlation of the homeostasis model assessment index and adiponectin, leptin and insulin levels to body mass index-associated gene polymorphisms in adolescents. Sultan Qaboos University Medical Journal،Vol. 18, no. 3, pp.291-298.
https://search.emarefa.net/detail/BIM-852785
Modern Language Association (MLA)
Mendieta Zeron, Hugo…[et al.]. Correlation of the homeostasis model assessment index and adiponectin, leptin and insulin levels to body mass index-associated gene polymorphisms in adolescents. Sultan Qaboos University Medical Journal Vol. 18, no. 3 (Aug. 2018), pp.291-298.
https://search.emarefa.net/detail/BIM-852785
American Medical Association (AMA)
Martinez, Maria D. Martinez& Mendieta Zeron, Hugo& Celis, Luis& Layton Tovar, Cristian F.& Torres Garcia, Rocio& Gutierrez Pliego, Laura E.…[et al.]. Correlation of the homeostasis model assessment index and adiponectin, leptin and insulin levels to body mass index-associated gene polymorphisms in adolescents. Sultan Qaboos University Medical Journal. 2018. Vol. 18, no. 3, pp.291-298.
https://search.emarefa.net/detail/BIM-852785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 297-298
Record ID
BIM-852785