The effect of Enalapril drug on some histological aspects of testes tissue in the mature albino male mice

Other Title(s)

دراسة تأثير عقار الأنالابريل في بعض النواحي النسجية لنسيج الخصيه في ذكور الفئران البيض البالغة

Joint Authors

Ali, Dina Khudayr Husayn
Musa, Abir Uthman

Source

Iraqi Journal of Science

Issue

Vol. 59, Issue 4A (31 Dec. 2018), pp.1843-1846, 4 p.

Publisher

University of Baghdad College of Science

Publication Date

2018-12-31

Country of Publication

Iraq

No. of Pages

4

Main Topic

Biology

Abstract EN

The study aimed to evaluate whether Enalapril has any effects on the testicular tissue of the albino male mice which received or did not receive treatment with Enalapril.

Mature mice were divided into three groups: control group which fed with 0.1mg of normal saline, the second group was orally fed with 10 mg/Kg of Enalapril drug while the third group was fed with 20 mg/Kg of drug, one time a day for 30 successive days by using gavage tube (0.1ml).

The histological sections were performed and the slides were examined using the light microscope.

The present study result of light microscopic images of mice testes cross sections which treated with 20 mg/Kg of Enalapril showed coagulated necrosis on spermatogonia germ cells, stopping the maturation in testicular tissue and ischematic alternations.

Furthermore, the group treated with 10 mg/Kg showed arresting of spermatozoa maturation, congestion of blood vessels and spreading of edema.

In comparison with the control group which demonstrated normal interstitial tissue and absence of edema with spermatogenic maturation observing numerous spermatozoa within the tubule lumen.

In conclusion, Enalapril might play a role in pathogenesis of testicular tissue and men infertility.

American Psychological Association (APA)

Musa, Abir Uthman& Ali, Dina Khudayr Husayn. 2018. The effect of Enalapril drug on some histological aspects of testes tissue in the mature albino male mice. Iraqi Journal of Science،Vol. 59, no. 4A, pp.1843-1846.
https://search.emarefa.net/detail/BIM-852832

Modern Language Association (MLA)

Musa, Abir Uthman& Ali, Dina Khudayr Husayn. The effect of Enalapril drug on some histological aspects of testes tissue in the mature albino male mice. Iraqi Journal of Science Vol. 59, no. 4A (2018), pp.1843-1846.
https://search.emarefa.net/detail/BIM-852832

American Medical Association (AMA)

Musa, Abir Uthman& Ali, Dina Khudayr Husayn. The effect of Enalapril drug on some histological aspects of testes tissue in the mature albino male mice. Iraqi Journal of Science. 2018. Vol. 59, no. 4A, pp.1843-1846.
https://search.emarefa.net/detail/BIM-852832

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1446

Record ID

BIM-852832