Aspartate aminotransferase and alanine aminotransferase in vaginal fluid for detecting preterm premature rupture of membrane

Abstract EN

Premature rupture of membranes (PROM) occurs in 2 % of pregnancies, and 30-40 % of preterm labors are related to this problem.

Early diagnosis of PPROM is very important due to its impact on pregnancy outcomes, false diagnosis of PPROM may lead to unnecessary obstetric interventions.

The aim of this study was to determine the diagnostic value of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in vaginal fluid for the diagnosis of preterm premature rupture of membranes as a non-invasive and available test.

Methods : A total of 100 pregnant women between the 28th-36th gestational weeks were enrolled in the study.

Fifty patients were in PPROM group and 50 in control group.

AST and ALT levels in vaginal fluid were measured in each group.

Mann Whitney U-test was used to compare AST and ALT levels in each group.

Results : The mean of AST level in vaginal fluid was 8.8 (5.5-17.2 IU / L) in PROM group versus 5.1 (2.98.2- IU / L) in control group (p < 0.001), sensitivity and specificity for AST was 80 %, 58 % respectively, while the ALT levels in PPROM group was 6.9 (4.5-15.2 IU / L) and in control group 4.6 (3.1-7.6 IU / L) (p < 0.004), the sensitivity and specificity was 78 %, 48 % respectively.

Conclusions : According to the findings of this study, the levels of AST and ALT in vaginal fluid were higher in the cases of PPROM than in the cases without PPROM.

The aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in vaginal fluid could be used as a predictive test for the diagnosis of PPROM.