Synthesis of a flavone based fluorescent probe bearing a Nitroolefin moiety for selective detection of cysteine
Other Title(s)
التحضير الكيميائي لكاشف ضوئي فلافوني يحتوي على مجموعة نيتروأولوفين للكشف الانتقائي للحمض الأميني سيستين
Joint Authors
Varghese, Beena
al-Busafi, Salih N.
al-Hammami, Nadiyah M.
Sulayman, Fakhr al-Din O.
Source
Sultan Qaboos University Journal for Science
Issue
Vol. 23, Issue 2 (31 Dec. 2018), pp.85-94, 10 p.
Publisher
Sultan Qaboos University College of Science
Publication Date
2018-12-31
Country of Publication
Oman
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
In this paper, we report the synthesis, characterization and investigation of the optical properties of a new fluorescent probe, 4ʹ-nitroolefinylflavone (4ʹ-NOF) 1, based on a flavone skeleton and bearing a nitroolefin moiety.
Upon the addition of cysteine, a remarkable fluorescence enhancement (200 fold) was observed for probe 1 accompanied with a slight blue shift from 457 nm to 459 nm.
The prepared probe displays high selectivity and sensitivity towards cysteine over other amino acids.
The Michael addition of cysteine to probe 1 was confirmed by 1H-NMR spectroscopy.
The detection limit of probe 1 towards cysteine was found to be 1.63 μΜ, a lower concentration than the normal human cysteine level, 30-200 μΜ.
American Psychological Association (APA)
al-Busafi, Salih N.& al-Hammami, Nadiyah M.& Sulayman, Fakhr al-Din O.& Varghese, Beena. 2018. Synthesis of a flavone based fluorescent probe bearing a Nitroolefin moiety for selective detection of cysteine. Sultan Qaboos University Journal for Science،Vol. 23, no. 2, pp.85-94.
https://search.emarefa.net/detail/BIM-853251
Modern Language Association (MLA)
al-Busafi, Salih N.…[et al.]. Synthesis of a flavone based fluorescent probe bearing a Nitroolefin moiety for selective detection of cysteine. Sultan Qaboos University Journal for Science Vol. 23, no. 2 (2018), pp.85-94.
https://search.emarefa.net/detail/BIM-853251
American Medical Association (AMA)
al-Busafi, Salih N.& al-Hammami, Nadiyah M.& Sulayman, Fakhr al-Din O.& Varghese, Beena. Synthesis of a flavone based fluorescent probe bearing a Nitroolefin moiety for selective detection of cysteine. Sultan Qaboos University Journal for Science. 2018. Vol. 23, no. 2, pp.85-94.
https://search.emarefa.net/detail/BIM-853251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 93-94
Record ID
BIM-853251