Primary gastric yolk sac tumour

Abstract EN

Primary gastric yolk tumours are extremely rare.

We report a 52-year-old male who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in 2017 after having undergone a gastrectomy abroad due to a suspected poorly-differentiated adenocarcinoma.

The patient subsequently returned to Oman to receive chemotherapy.

However, while undergoing chemotherapy, an abdominal computed tomography scan revealed a lobulated mesenteric mass.

Microscopic examination of the resected lesion confirmed a diagnosis of a yolk sac tumour.

The mass was diffusely positive for α-fetoprotein (AFP) and a gastric carcinoma stain was negative.

Gastrectomy slides from the patient’s previous surgery were examined retrospectively.

The morphology was typical for a yolk sac tumour and was negative for epithelial markers.

An AFP stain showed diffuse immunoreactivity.

Thus, the patient was deemed to have had a primary gastric yolk sac tumour which had later metastasised to the mesocolon.

Germ cell tumour protocols were initiated and the patient responded well to treatment.