Evaluation of administration of hibiscus rosa sinensis (HRS)‎ leaves, pomegranate (punica granatum)‎ peels (PP)‎ extracts and mixture of both on lipid profile of albino rats

Abstract EN

The possible lipid lowering properties of aqueous extracts of hibiscus rosa sinensis leaves (aehrs) and pomegranate (punica granatum) peels (aepp) were studied.

twelve groups of male albino rats, six rats each were used.

the first group (i) was the normal control.

the second group (ii) was alloxanized diabetic control which showed a significant dyslipidemia as evidence by increasing in total serum cholesterol, triglycerides and decreased in hdl cholesterol level.

third (iii), fourth (iv) and fifth (v) groups were given aehrs with the dose level of ٢٥٠, ٥٠٠ and ٧٥٠ mg/kg body weight, respectively.

sixth (vi), seventh (vii) and eighth (viii) groups were received aepp extracts with the dose level of ١٠٠, ٢٠٠ and ٣٠٠ mg/kg body weight, respectively.

ninth (ix), tenth (x), eleventh (xi) groups were given mixture of aehrs and aepp with the dose level of ١٢٥/١٢٥,٢٢٥/٢٢٥, ٣٥٠/٣٥٠ and one for diabetic rats which treated with a mixture of aehrs leaves and aepptwelfth (xii)- at dose of ٤٠٠/٤٠٠ mg/kg body weight.

all treated groups were given the extracts daily oral.

total serum cholesterol (tc), triglyceride (tg) and high density lipoprotein cholesterol (hdl-c) were determined after ٧, ١٤ and ٢١ days.

the results showed a decrease in serum cholesterol from١٥٩.٥٥٨.٢٢ to ١٣٦.٦٤ ٩.٠٧ mg/dl, triglycerides levels from ١٤١.٠٠٤.٦ to ١١٥.٩١٢.١٧mg/dl and an increase of high density lipoprotein cholesterol level from ٦٩.٣١٠.٨٤ to ١١١.٣١١.١٣mg/dl in groups administrated aehrs leaves, aepp and their mixture as compared with normal control and alloxanized diabetic control.

the present results indicated that the aqueous extracts of (hrs leaves), (pp) and their mixture possess hypo-cholesterolemic and hypotriglyceridemic effects.