Association between post treatment existence of HCV RNA positive strand and or negative strand in the pbmncs and HCV relapse
Joint Authors
al-Dhahabi, Amjad Ali Abd al-Hadi
Sulayman, Jamal Muhammad Muhammad
Qurani, Muhammad Abd Allah
al-Tayyibi, Diya Muhammad
al-Wadi, Mustafa Kamil
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 47, Issue 2 (31 Aug. 2017), pp.323-330, 8 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2017-08-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Economics & Business Administration
Abstract EN
Hepatitis C virus (HCV) has been found to infect peripheral blood mononuclear cells (PBMCs), using them as a reservoir, which might contribute to development of resistance to treatment.
The study evaluated the predictive value of existence of HCV RNA in PBMCs of chronic hepatitis C patients and its association with HCV seroconversion following the completion of therapy with di-rect antiviral agents (DAAs).
Methods: 58 Egyptian patients were included with chronic HCV in-fection who achieved negative serum HCV RNA after completion of therapy with DAAs.
HCV RNA in PBMCs and serum was investigated at the end of treatment and 12 weeks later.
At the end of treatment patients were subdivided into three groups.
GA: included 23 patients with negative (positive & negative strands of HCV RNA) in PBMCs.
GB: included 24 patients with positive (positive strand) of HCV RNA in PBMNCs.
GC: included 11 patients with positive (positive & negative strands of HCV RNA) in PBMCs.
The results showred that 16 relapsers out of 58 patients (27.59 %).
GA only one patient out of 23 (4.3 %) failed to achieve SVR.
so the absence of HCV RNA in PBMNCs is associated with high SVR rate (95.7%).GB 10/24 patients failed to achieve SVR, so the presence of HCV RNA posi-tive strand in PBMNCs is associated with high relapse rate (41.7 %), GC 5/11 patients failed to achieve SVR.
where the presence of HCV RNA (negative replicative and positive genomic strands) in PBMNCs is associated with higher rate of relapse (45.45%).
American Psychological Association (APA)
al-Dhahabi, Amjad Ali Abd al-Hadi& Sulayman, Jamal Muhammad Muhammad& Qurani, Muhammad Abd Allah& al-Tayyibi, Diya Muhammad& al-Wadi, Mustafa Kamil. 2017. Association between post treatment existence of HCV RNA positive strand and or negative strand in the pbmncs and HCV relapse. Journal of the Egyptian Society of Parasitology،Vol. 47, no. 2, pp.323-330.
https://search.emarefa.net/detail/BIM-857748
Modern Language Association (MLA)
al-Tayyibi, Diya Muhammad…[et al.]. Association between post treatment existence of HCV RNA positive strand and or negative strand in the pbmncs and HCV relapse. Journal of the Egyptian Society of Parasitology Vol. 47, no. 2 (Aug. 2017), pp.323-330.
https://search.emarefa.net/detail/BIM-857748
American Medical Association (AMA)
al-Dhahabi, Amjad Ali Abd al-Hadi& Sulayman, Jamal Muhammad Muhammad& Qurani, Muhammad Abd Allah& al-Tayyibi, Diya Muhammad& al-Wadi, Mustafa Kamil. Association between post treatment existence of HCV RNA positive strand and or negative strand in the pbmncs and HCV relapse. Journal of the Egyptian Society of Parasitology. 2017. Vol. 47, no. 2, pp.323-330.
https://search.emarefa.net/detail/BIM-857748
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 329-330
Record ID
BIM-857748