A review on the role of HLA-G in fetal-maternal immuno-tolerance
Other Title(s)
دراسة مرجعية : دور مستضدات الكريات البيضاء البشرية (HLA-G) في التجاوز المناعي بين الأم و الجنين
Author
al-Abd al-Munim, Walid Ibrahim
Source
Journal of the North for Basic and Applied Sciences
Issue
Vol. 3, Issue 2 (30 Nov. 2018), pp.175-192, 18 p.
Publisher
Northern Border University Scientific Publishing Center
Publication Date
2018-11-30
Country of Publication
Saudi Arabia
No. of Pages
18
Main Subjects
Abstract EN
Immunological interactions that involve Major Histocompatibility Complex (MHC) antigens at the fetal-maternal interface are associated with reproductive success.
MHC Class Ib antigens present on the trophoblast cell-surface structurally resemble HLA-G suggesting that Human Leukocyte Antigen G (HLA-G) might be working in association with other MHC Class I partners to promote the inhibition of the cytotoxicity of Natural Killer (NK) cells at the fetal-maternal interface.
As per the laws of Immunology, the developing fetus should be rejected rather than protected.
The development of the fetus in the uterine environment is a classic example of a semi-allogenic graft.
However, the complex immunological mechanisms that involve the acceptance of the fetus and the placenta that are actually semi-allogenic to the mother- are not completely understood.
In this study, the graft is assumed to be granted with immune privilege by the controlled trophoblast MHC expression in the fetal-maternal interface.
The study also reviews the importance of HLA-G production at the fetal-maternal interface and discuss its relevance to human embryonic development.
American Psychological Association (APA)
al-Abd al-Munim, Walid Ibrahim. 2018. A review on the role of HLA-G in fetal-maternal immuno-tolerance. Journal of the North for Basic and Applied Sciences،Vol. 3, no. 2, pp.175-192.
https://search.emarefa.net/detail/BIM-861107
Modern Language Association (MLA)
al-Abd al-Munim, Walid Ibrahim. A review on the role of HLA-G in fetal-maternal immuno-tolerance. Journal of the North for Basic and Applied Sciences Vol. 3, no. 2 (Nov. 2018), pp.175-192.
https://search.emarefa.net/detail/BIM-861107
American Medical Association (AMA)
al-Abd al-Munim, Walid Ibrahim. A review on the role of HLA-G in fetal-maternal immuno-tolerance. Journal of the North for Basic and Applied Sciences. 2018. Vol. 3, no. 2, pp.175-192.
https://search.emarefa.net/detail/BIM-861107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 187-192
Record ID
BIM-861107