Serum heat shock protein 27 (sHSP27)‎ in a group of type 1 diabetic children and adolescents : relationship to microvascular complications

Abstract EN

Background: There is increased prevalence of T1DM in children and adolescents with its adverse complications especially microvascular ones (retinopathy, nephropathy and neuropathy) that might cause multiple organ damage.

Heat shock protein 27 (HSP27 or HSPB1) appears to be generally cytoprotective; its decrease may be a primary factor leading to the development of diabetes and its diverse chronic microvascular complications with widespread organ damage.

Ainu to measure serum Heat shock protein 27 (sHSP27) level in a group of type 1 diabetic Children and adolescents and to investigate its relationship with diabetic microvascular complications.

Subjects and Methods: This case control study was executed in the Diabetes Clinic and the outpatient clinic.

Children's Hospital, Ain Shams University.

June 2013- June 2015 This study was carried out on 60 children and adolescents with type 1 diabetes mellitus, there ages ranged between (8-18) years compared with 60 apparently healthy children matched as regards their age, sex, and socioeconomic Status.

Serum heat shock protein 27 (sHSP27) estimation was done by ELIZA technique.

Results: Serum HSP27 was statistically significantly lower in diabetic patients with complications (6.19+ 1.17) than diabetic patients without complications (8.72+ 1.95) and controls (12.29± 2.08).

The diabetic neuropathy was accompanied by most decrease in the level of HSP27 among diabetic patients with microvascular complications.

Conclusion: decreased Serum heat shock protein 27 (sHSP27), indicative of decreased defense mechanism in type 1 diabetes, this decrease was more profound in patients with microvascular complications especially these who developed diabetic neuropathy.