Synthesis, characterization of poly heterocyclic compounds, and effect on cancer cell (Hep-2) in vitro
Other Title(s)
تخليق، تشخيص مركبات غير المتجانسة متعددة، و تأثيرها على الخلايا السرطانية (Hep-2) خارج الخلية
Joint Authors
Abd Allah, Ibtihal Qahtan
Nayif, Ulfat Abd
Jasim, Marwah Nasif
al-Zahawi, Halah Muhammad Gharib
Source
Issue
Vol. 15, Issue 4 (31 Dec. 2018), pp.415-424, 10 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
synthesis series of new heterocyclic derivatives (A2-A7) (pyrrole, pyridazine, oxazine and imidazol) derived from 4-acetyl-2,5-dichloro-1-(3,5-dinitrophenyl)-1H-pyrrole-3-carboxylate(A1) have been synthesised.
Synthesis of compound (A2) by the reaction of starting material (A1) with hydroxyl amine hydrochloride in the presence of pyridine.
Compound (A2) was reacted with hydrazine hydrate in dry benzene to give (A3) derivative.
The compound )A3( deals with sodium nitrite to give diazonium salt, and the reaction diazonium salt with ethyl acetoacetate to produce compound (A4).
To a mixture of compound (A4) and hydroxyl amine with sttired to yield (A5).Compound (A6) was prepared by reaction compound (A4) with thiosemicarbazide in presence of drops of acetic acid.
Synthesis of 1compound (A7) by reaction compound (A6) with ethyl chloro acetate.
The reactions have been monitored by TLC and the synthesized compounds were characterized using spectrophotometric methods FT-IR, 1H NMR.The biological effects of the prepared compounds on the cancer cells were studied in vitro.
The results indicated that these Synthesized compounds (A1–A7) inhibited1 the cancer1 cells1 efficiently, the compound (A6) was activity inhibited on the cancer cells
American Psychological Association (APA)
Nayif, Ulfat Abd& Abd Allah, Ibtihal Qahtan& al-Zahawi, Halah Muhammad Gharib& Jasim, Marwah Nasif. 2018. Synthesis, characterization of poly heterocyclic compounds, and effect on cancer cell (Hep-2) in vitro. Baghdad Science Journal،Vol. 15, no. 4, pp.415-424.
https://search.emarefa.net/detail/BIM-866084
Modern Language Association (MLA)
Nayif, Ulfat Abd…[et al.]. Synthesis, characterization of poly heterocyclic compounds, and effect on cancer cell (Hep-2) in vitro. Baghdad Science Journal Vol. 15, no. 4 (2018), pp.415-424.
https://search.emarefa.net/detail/BIM-866084
American Medical Association (AMA)
Nayif, Ulfat Abd& Abd Allah, Ibtihal Qahtan& al-Zahawi, Halah Muhammad Gharib& Jasim, Marwah Nasif. Synthesis, characterization of poly heterocyclic compounds, and effect on cancer cell (Hep-2) in vitro. Baghdad Science Journal. 2018. Vol. 15, no. 4, pp.415-424.
https://search.emarefa.net/detail/BIM-866084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 423
Record ID
BIM-866084