New spectrophotometric estimation and cloud point extraction of cefdinir
Other Title(s)
طريقة طيفية جديدة لتقدير السيفدينير بالاستخلاص بنقطة الغيمة
Joint Authors
Hasan, Muhammad Jasim Muhammad
Muzhir, Umar Qusayy
Source
Issue
Vol. 15, Issue 4 (31 Dec. 2018), pp.425-435, 11 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
A sensitive spectrophotometric method was developed for the estimation of cefdinir (CFD), a cephalosporin species.
This study involves two methods, and the first method includes the preparing of azo dye by the reaction of CFD diazonium salt with 4-Tert-Butylphenol (4-TBP) and 2-Naphthol (2-NPT) in alkaline medium, which shows colored dyes measured at λmax 490 and 535 nm, respectively.
Beer's law was obeyed along the concentration range of (3-100) μg.ml-1.
The limits of detection were 0.246, 0.447 μg.ml-1 and molar absorptivities were 0.6129×104, 0.3361×104 L.mol-1cm-1 for (CFD-4-TBP) and (CFD-2-NPT), respectively.
The second method includes preconcentration for cefdinir dyes by using cloud point extraction in the presence of Triton X-114 (10% v/v) and recording measurements using the UV-Visible technique.
Cloud point extraction enables the drug to be precisely estimated under the optimal experimental conditions.
The concentrations were ranged between (0.1-6.0) and (0.2-6.0) μg.ml-1.
The limits of detection were 0.032, 0.054 μg.ml-1 and molar absorptivities were 0.4733×105, 0.2788×105 L.mol-1cm-1, respectively.
Enrichment factors were 24.61, 24.58, and distribution coefficients were 1526, 1393 for (CFD-4-TBP), (CFD-2-NPT), respectively.
The proposed methods have been applied for the determination of CFD in commercial formulation with no interference.
The results appear to be no significant difference between the two methods.
American Psychological Association (APA)
Hasan, Muhammad Jasim Muhammad& Muzhir, Umar Qusayy. 2018. New spectrophotometric estimation and cloud point extraction of cefdinir. Baghdad Science Journal،Vol. 15, no. 4, pp.425-435.
https://search.emarefa.net/detail/BIM-866087
Modern Language Association (MLA)
Hasan, Muhammad Jasim Muhammad& Muzhir, Umar Qusayy. New spectrophotometric estimation and cloud point extraction of cefdinir. Baghdad Science Journal Vol. 15, no. 4 (2018), pp.425-435.
https://search.emarefa.net/detail/BIM-866087
American Medical Association (AMA)
Hasan, Muhammad Jasim Muhammad& Muzhir, Umar Qusayy. New spectrophotometric estimation and cloud point extraction of cefdinir. Baghdad Science Journal. 2018. Vol. 15, no. 4, pp.425-435.
https://search.emarefa.net/detail/BIM-866087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 434-435
Record ID
BIM-866087