فعالية الكارفيديلول و سلامته في الاعتلال التوسعي للعضلة القلبية عند الأطفال
Other Title(s)
Efficacy and safety of carvedilol in children with dilated cardiomyopathy
Author
Source
Issue
Vol. 31, Issue 2 (31 Dec. 2015), pp.9-16, 8 p.
Publisher
Publication Date
2015-12-31
Country of Publication
Syria
No. of Pages
8
Main Subjects
Abstract EN
Background & Objective: Dilated Cardiomyopathy is characterized by dilated and contractile dysfunction of left ventricle, is defined in terms of Hemodinamically by a decrease in left ventricle ejection fraction less than 50%.To evaluated the clinical effect of Carvedilol among pediatric patients with dilated cardiomyopathy (DCM) who did not responded to standard therapy.
Methods & Materials: we performed a prospective study over 3 years in 15 Children (10 male , 5 female) – the mean age was (34.7±5) months (range: 5 months- 9 years), all had been treated with conventional medications (digoxin, diuretics, angiotensin-converting enzyme inhibitors) for more than 3 months before starting Carvedilol.
All patients received an initial dose of 0.05 mg/kg/day in two divided doses.
Cardevilol dose was increased weekly to achieve 1.2 mg/kg/day in 6 months.
Left ventricular function on echocardiography (EF,FS,VCFc) was obtained before and during Carvedilol therapy, in addition to modified ROSS score and modified New York Heart Association functional class in children, at follow up of six months Results: The modified ROSS score improved in (12) patients (80)%.
Left ventricular EF, Left ventricular FS and VCFc improved from 26.8±8% to 41.7±18% and from 14.8±3% to 21±9% and from 0.52±0.05 circ/s to 0.76±0.14 circ/s respectively.
Conclusion: the results of present study indicate that Carvedilol improves ventricular function and symptoms in children with DCM, it is well tolerated with minimal adverse effects.
American Psychological Association (APA)
سرور، سمير. 2015. فعالية الكارفيديلول و سلامته في الاعتلال التوسعي للعضلة القلبية عند الأطفال. مجلة جامعة دمشق للعلوم الطبية،مج. 31، ع. 2، ص ص. 9-16.
https://search.emarefa.net/detail/BIM-873158
Modern Language Association (MLA)
سرور، سمير. فعالية الكارفيديلول و سلامته في الاعتلال التوسعي للعضلة القلبية عند الأطفال. مجلة جامعة دمشق للعلوم الطبية مج. 31، ع. 2 (2015)، ص ص. 9-16.
https://search.emarefa.net/detail/BIM-873158
American Medical Association (AMA)
سرور، سمير. فعالية الكارفيديلول و سلامته في الاعتلال التوسعي للعضلة القلبية عند الأطفال. مجلة جامعة دمشق للعلوم الطبية. 2015. مج. 31، ع. 2، ص ص. 9-16.
https://search.emarefa.net/detail/BIM-873158
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 16
Record ID
BIM-873158