Preparation and in vitro evaluation of oral disintegrating salbutamol sulfate tablets using weak effervescent base

Abstract EN

The purpose of this research was to prepare orally disintegrating tablets (ODTs) of Salbutamol Sulfate by using weak effervescent base (calcium carbonate plus citric acid) as a disintegrating agent, the results were compared with the results of Crosspovidone cl (CPcl), and Crosscarmellose sodium (CCs) as superdisintegrants in ODTs.

Differential scanning calorimetric studies did not indicate any excipients incompatibility.

Tablets were prepared by direct compression method.

F2 showed disintegration time of 12 sec, and the wetting time was 20 sec.

F2 was achieved faster and regularly released of drug within 20 minutes, while the disintegrating and wetting times were increased in tablets containing Crosspovidone cl or Crosscarmellose sodium.

Orally disintegrating tablets of Salbutamol Sulfate with temporal disintegration and less wetting times were achieved via using weak effervescent base at 10% concentration.