دراسة التأثير الموسع الوعائي لنبات الزعرور Crataegus laevigata في الشريان الأبهر المعزول من الأرنب

Abstract EN

The Background and the Aim: The vasodilator effect of ethanolic extract of Crataegus laevigata (Rosaceae) was investigated in isolated and Norepinephrine-precontracted rabbit aortic rings.

Materials and Methods: The ethanolic extract was investigated in endothelium-intact aortic rings which were contracted by NE.

In another segment of groups, the same experiments were repeated in endothelium-denuded aortic rings.

The vasodilator drugs: Diltiazem and Prazocine were used as references and for evaluative tools.

Results: This extract showed a profound relaxing effect on NE-precontracted aortic rings, which was partially related to endothelium.

Conclusion: the vasodilator effect of ethanolic extract of Crataegus laevigata is partially related to endothelium.

this emphasizes the need for isolation of related compound(s)