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Molecular subtypes of breast cancer
Joint Authors
al-Marzuq, Raid Hamid
al-Rayyis, Amal Ahmad Nur
al-Aradi, Husayn
Abd Allah, Husayn
Source
Issue
Vol. 40, Issue 4 (31 Dec. 2018), pp.222-225, 4 p.
Publisher
King Hamad University Hospital
Publication Date
2018-12-31
Country of Publication
Bahrain
No. of Pages
4
Main Subjects
Abstract EN
Background: Breast cancer is the most common invasive malignancy among women in Bahrain.
Hormone receptor status and human epidermal growth factor receptor 2 (HER2) protein overexpression are important parameters in determining the therapeutic options and patient prognosis.
Objective: To evaluate the prevalence of estrogen (ER), progesterone (PR) and HER2 receptor status and as well as the molecular subtypes of breast cancer in Bahrain compared with those reported in other countries.
Design: A Retrospective Study.
Setting: Salmaniya Medical Complex, Bahrain.
Method: Two hundred eighty-six female breast cancer patients were included in the study.
Data collected included patient age, tumor type, ER, PR and HER2 receptor status, and molecular subtypes.
The data were analyzed using SPSS version 25.
Result: One hundred eighty-eight (65.7%) were ER-positive tumors.
One hundred sixty-five (57.8%) PR receptors were positive.
Eighty-nine (31.1%) patients had HER2 amplification.
One hundred forty-seven (51.4%) cancers were Luminal A and 48 (16.8%) were Luminal B subtype.
Forty-one (14.3%) tumors were HER2-type and 50 (17.5%) had triple negative breast cancers among females.
Correlation between age and immunohistochemistry (IHC) receptor status was not statistically significant.
Conclusion: The prevalence of molecular subtypes of breast cancer showed some variation among the regional population.
Among females in Bahrain, the proportion of HER2-type and triple negative breast cancers is higher than other regional countries
American Psychological Association (APA)
al-Marzuq, Raid Hamid& al-Rayyis, Amal Ahmad Nur& al-Aradi, Husayn& Abd Allah, Husayn. 2018. Molecular subtypes of breast cancer. Bahrain Medical Bulletin،Vol. 40, no. 4, pp.222-225.
https://search.emarefa.net/detail/BIM-874372
Modern Language Association (MLA)
al-Marzuq, Raid Hamid…[et al.]. Molecular subtypes of breast cancer. Bahrain Medical Bulletin Vol. 40, no. 4 (Dec. 2018), pp.222-225.
https://search.emarefa.net/detail/BIM-874372
American Medical Association (AMA)
al-Marzuq, Raid Hamid& al-Rayyis, Amal Ahmad Nur& al-Aradi, Husayn& Abd Allah, Husayn. Molecular subtypes of breast cancer. Bahrain Medical Bulletin. 2018. Vol. 40, no. 4, pp.222-225.
https://search.emarefa.net/detail/BIM-874372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 224-225
Record ID
BIM-874372