Igf-i in relatives of women with breast cancer

Abstract EN

Insulin-like growth factor-I or somatomedin-C is a 70 amino acid residue which mediates the action of growth hormone, it promote ductal elongation and stimulate alveolar bud development in mammary tissues, it increases mitogenic activity of breast tissue over an extended period of time and presumably renders the breast more susceptible to malignant transformation by decreasing the time available for DNA repair mechanisms to function.

High circulating IGF-I and estrogens act synergistically on pathogenesis of breast cancer thus elevated circulating levels of IGF-I may be an indicator of increased risk of breast cancer occurring before age 50. PATIENTS AND METHODS: the study comprised fifty-five premenopausal female aged 20-50 years.

The study subjects were classified into two groups: Group I: consists of 35 female who are relatives of breast cancer patients with mean age 33.6 ±8.96 and mean BMI 31.6 ±8.1 Kg / m² furthermore they are subdivided according to their age into 3 age groups 20-30Y&30-40Y&40-50Y.Group II: consists of twenty healthy female with no family history of cancer breast as a control group, their mean age 31.6±7.8 years and mean BMI 24.2±2.7 Kg / m².

all females are subjected to full medical history, anthropometric measurement, full blood chemistry with detailed lipid profile(total cholesterol, triglycerides, LDL and HDL) and insulin like Growth factor-I (IGF-I). RESULTS: IGF-I was significantly high in group I, age group 20-30Y (P<0.01) when compared to the control age matched females moreover, high significant negative correlation (P<0.05) with total age, weight, waist circumference.

Also IGF-I shows insignificant negative correlation with BMI& current height (P>0.05) and No correlation was found between serum IGF-I and lipid profile. RESULTS: IGF-I was significantly high in group I, age group 20-30Y (P<0.01) when compared to the control age matched females moreover, high significant negative correlation (P<0.05) with total age, weight, waist circumference.

Also IGF-I shows insignificant negative correlation with BMI& current height (P>0.05) and No correlation was found between serum IGF-I and lipid profile. CONCLUSION: IGF-I significantly elevated in the relatives of Breast cancer patients in the age range from 20-30 Y only than age matched control group, however in total, there is no significant difference between the two groups.

So this age group needs to be followed for years as they expected if they develop breast cancer, this will be during their 4th or 5th decade of life.

And if this occurs it will be an evidence that serum IGF-I is an early biomarker of breast cancer.