Assessment of lipid peroxidation and glutathione levels in serum and seminal plasma for unexplained infertile men in Thi-Qar Governorate

Abstract EN

Infertility is the inability of a sexually active, non-contracepting couple to achieve spontaneous pregnancy in one year.

unexplained male infertility (UMI) is reserved for infertile of unknown origin and accounts for 6-27% of infertile men with normal semen analyses on two or more occasions with no demonstrable physical or endocrine abnormalities and female factor infertility has been ruled out.

Oxidative stress (OS) is a consequence of an imbalance between the production of reactive oxygen species(ROS) and the body’s antioxidant defense mechanisms.

However oxidative stress(OS) is a common pathology seen in approximately half of all infertile men.

It has been shown that reactive oxygen species (ROS) can lead to deleterious effects on a range of sperm parameters.

The monitoring of MDA levels in different biological systems can be used as an important indicator of lipid peroxidation .Humans have developed a highly ,organized and complex antioxidant defense system to protection cells and organ systems of the body against reactive oxygen species(ROS) such as glutathione is capable of reducing ROS levels and lipid peroxidation..

Serum and seminal plasma MDA was significantly increased in unexplained infertile(smoker and nonsmoker)groups when compared to fertile (smoker and nonsmoker)groups.

The serum and seminal plasma glutathione were significantly decreased in unexplained infertile( smoker and nonsmoker)groups when compared to fertile (smoker and nonsmoker)groups.

The decrease in antioxidant levels appears to be mainly a consequence of increased oxidative stress.