Carotid artery intima-media thickness in adolescents with type-1 diabetes

Abstract EN

Diabetes mellitus is a chronic metabolic disorder characterized by long-term complications, including retinopathy, nephropathy, and neuropathy, all of which are closely related to vascular damage.

Studies concerning the pathogenesis, complications, and metabolic control of diabetes are still continuing.

Adiponectin is a novel adipose-specific protein with putative antiatherogenic and anti-inflammatory effects.

Adrenomedullin (ADM) is a vasorelaxing peptide produced from endothelium and smooth muscle cells.

It may act as an antiproliferative factor for vascular smooth muscle cells.

ADM is known to decrease the levels of insulin and delay insulin response to oral glucose.

The aim of this work is to study the clinical relevance of adiponectin and adrenomedullin in diabetic patients both type 1 and type 2 with and without micro vascular diabetic complications ,and assess their role in pathogenesis of these complications This study included 80diabetic patients (45with type 2 diabetes, and 35 with type 1).

Serum adrenomedullin and adiponectin levels were studied in the various patients groups (complicated and non-complicated), and subsequently compared with the control group.

There was a highly significant decrease in adiponectin levels and an increase in adrenomedullin levels in complicated diabetics groups Ib (complicated type 2 diabetes) and IIb (complicated type 1 diabetes)than the control.

Meanwhile, results of diabetics without complications (group Ia, and IIa), were insignificantly different from control.

Adiponectin concentrations correlated negatively with both serum fasting glucose and glycated hemoglobin and positively with creatinine.

Concerning adrenomedullin, there was a highly significant positive correlation with fasting serum glucose creatinine, and glycated hemoglobin and a negative correlation with adiponectin.

These results indicate that the increase in plasma adrenomedullin was closely related to diabetic micro vascular complications, which may lead to the development of micro angiopathy.

We can also conclude that adiponectin not only a good marker for monitoring of glyceamic control as evidenced by the highly significant correlation with.