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A study on serum lactoferrin in type 2 diabetic with recurrent and chronic skin and soft tissue infection
Joint Authors
Ismail, Samiyah
Abd al-Aziz, Majdi Abbas
al-Dib, Abd al-Sattar
Shukri, Majidah
Gharib, Muhammad A.
Ahmad, Yara M.
Source
Egyptian Journal of Applied Endocrinology
Issue
Vol. 23, Issue 1-2 (30 Jun. 2005), pp.163-173, 11 p.
Publisher
The Egyptian Society of Applied Endocrinology
Publication Date
2005-06-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
Background: Diabetes mellitus is commonly associated with skin and soft tissue infection, which may be a consequence of altered immune system in DM.
Lactoferrin, a naturally occurring protein, is suggested to play a role in general defense against bacterial infections.
Objective: to study the possible relation between skin and soft tissue infectins in patients with type 2 DM and serum lactoferrin level.
Study Design: the study was conducted on 50 subjects recruited from Ain Shams University Hospital, 40 diabetic patients; 20 patients with type 2 DM with no skin or soft tissue infections & 20 type 2 diabetic patients with skin or soft tissue infections and 10 healthy subjects were selected as a control group.
All subjects were subjected to full history, glycemic indices including FBG, PPG and glycated hemoglobin (HbA1c), bacterial culture & direct staining in patients with infection, and serum lactoferrin level by ELISA.
Results: Diabetic patients with infection had significant poorer glycemic control (FBG 303.5 + 102.95 mg / dl PPG 340.8 + 32.61 mg/dl & HbA1c ( 12.31 + 1.4%) compared to diabetic patients without infection (FBG 201.2 + 83.97 mg / dl, PPG 249.3 + 79.49 ng /dl & HbA1c 10.06 + 1.71%).
Lactoferrin was significantly lower in the group with infection (201.14 + 80.91 ng /dl) than in the diabetic without infection ( 293.75 + 72.88 ng/dl) and the control group (410.6 + 83.39 mg /dl) P<0.01.
Non-significant correlation was detected in this study between serum lactoferrin level and all glycemic indices (FBG, PPG and HbA1c).
American Psychological Association (APA)
Gharib, Muhammad A.& al-Dib, Abd al-Sattar& Shukri, Majidah& Ahmad, Yara M.& Abd al-Aziz, Majdi Abbas& Ismail, Samiyah. 2005. A study on serum lactoferrin in type 2 diabetic with recurrent and chronic skin and soft tissue infection. Egyptian Journal of Applied Endocrinology،Vol. 23, no. 1-2, pp.163-173.
https://search.emarefa.net/detail/BIM-87740
Modern Language Association (MLA)
Gharib, Muhammad A.…[et al.]. A study on serum lactoferrin in type 2 diabetic with recurrent and chronic skin and soft tissue infection. Egyptian Journal of Applied Endocrinology Vol. 23, no. 1-2 (Jun. 2005), pp.163-173.
https://search.emarefa.net/detail/BIM-87740
American Medical Association (AMA)
Gharib, Muhammad A.& al-Dib, Abd al-Sattar& Shukri, Majidah& Ahmad, Yara M.& Abd al-Aziz, Majdi Abbas& Ismail, Samiyah. A study on serum lactoferrin in type 2 diabetic with recurrent and chronic skin and soft tissue infection. Egyptian Journal of Applied Endocrinology. 2005. Vol. 23, no. 1-2, pp.163-173.
https://search.emarefa.net/detail/BIM-87740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 170-171
Record ID
BIM-87740