The relation of insulin – like growth factor-1 and insulin – like growth factor binding proteins in umbilical cord plasma to preeclampsia and infant birth weight
Joint Authors
al-Mawsili M.
Kortam M. A.
Shoeib, Nihad Shukri
Source
Egyptian Journal of Applied Endocrinology
Issue
Vol. 23, Issue 1-2 (30 Jun. 2005), pp.211-222, 12 p.
Publisher
The Egyptian Society of Applied Endocrinology
Publication Date
2005-06-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Objective: to find out whether preeclampsia is associated with alterations in insulin–like growth factor-1 (IGF-1) and its binding proteins: insulinlike growth factor binding proteins 1 and 3 (IGFBP 1 and 3) independent from the changes attributed to reduced birth weight.
Patients & Methods: The study included 150 pregnant women in labor from Ain Shams University Maternal Hospital who were divided into 3 equal groups: Group (1) severe preeclampsia (PE), group (2) mild PE and group (3) normotensive (control) groups.
Cord blood was collected from each participant for measurement of plasma IGF-1, IGFBP1 and IGFBP-3.
Neonatal weight was recorded after delivery and fetal growth was expressed as the ratio between the observed and expected birth weights.
-Results: There were no differences between mild PE and controls regarding IGF-1, IGFBP-1 and IGFBP-3.
In severe and early onset PE, umbilical cord plasma IGF-1 was significantly lower (P < 0.01) and IGFBP-1 was The Relation of Insulin Nehad Shoeib, et al significantly higher (P <0.01) than in controls.
For each birth weight, IGF-1 was lower and IGFBP-1 was higher in severe or early PE than among controls of similar weight.
Birth weight and PE were, independent of each other, associated with IGF-1 whereas birth weight but not PE, was associated with IGFBP-1, after adjustment of gestational age. Conclusion: Fetal growth restriction caused by severe or early PE is associated with lower umbilical levels of IGF-1 than low birth weight caused by other conditions.
PE may contribute to the observed IGF-1 reduction either as part of the underlying causes of PE or as a consequence of the disease
American Psychological Association (APA)
Shoeib, Nihad Shukri& Kortam M. A.& al-Mawsili M.. 2005. The relation of insulin – like growth factor-1 and insulin – like growth factor binding proteins in umbilical cord plasma to preeclampsia and infant birth weight. Egyptian Journal of Applied Endocrinology،Vol. 23, no. 1-2, pp.211-222.
https://search.emarefa.net/detail/BIM-87800
Modern Language Association (MLA)
Shoeib, Nihad Shukri…[et al.]. The relation of insulin – like growth factor-1 and insulin – like growth factor binding proteins in umbilical cord plasma to preeclampsia and infant birth weight. Egyptian Journal of Applied Endocrinology Vol. 23, no. 1-2 (Jun. 2005), pp.211-222.
https://search.emarefa.net/detail/BIM-87800
American Medical Association (AMA)
Shoeib, Nihad Shukri& Kortam M. A.& al-Mawsili M.. The relation of insulin – like growth factor-1 and insulin – like growth factor binding proteins in umbilical cord plasma to preeclampsia and infant birth weight. Egyptian Journal of Applied Endocrinology. 2005. Vol. 23, no. 1-2, pp.211-222.
https://search.emarefa.net/detail/BIM-87800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 221-222
Record ID
BIM-87800