Preparation, characterization and biological activity study of some new thiazolidine derivatives
Other Title(s)
تحضير و تشخيص و دراسة الفعالية البايولوجسية لبعض مشتقات الثايزولدين الجديدة
Joint Authors
Hasan, Ayat Naji
Abd, Dawud Salim
Source
Journal of Basrah Researches : Sciences
Issue
Vol. 43, Issue 1A (31 Mar. 2017), pp.10-29, 20 p.
Publisher
University of Basrah College of Education for Pure Sciences
Publication Date
2017-03-31
Country of Publication
Iraq
No. of Pages
20
Main Subjects
Abstract EN
Thiazolidine-4-carboxylic acid is a cyclic sulfur amino acid, analogous in its structure to proline, a condensation product of cysteine and formaldehyde.
Thiazolidine and N-acetyl derivative were reported to possess biological activity and both compounds that also tested for clinical use.
The study included synthesis of some thiazolidine derivatives [1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h] which were prepared from reaction of cysteine with benzaldehyde and its derivatives under private conditions.
This reaction produces a mixture of isomers , Cis- (2S, 4S) and Trans- ( 2R, 4S), which could not be Separated, An equilibrium resulting from epimerization at C(2) occurs between two isomers, The Cis/Trans ratios were strongly dependent on the nature of the solvent.
These compounds above react with acetic anhydride to prepare the compounds [2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h] and which represents reaction protection for an amine group, Then these latter compounds react with the amine (2-amino-6-ethoxy benzothiazole) to form compounds thiazolidine-4-carboxylic amide [3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h] .
The new synthesized compounds were identified by melting points and FT-IR, 1HNMR, 13CNMR and mass spectrum.
The biological activities of some preparation compounds were studied against two types of bacteria one of them were gram negative (Klebsiella Pneumonia) and other were gram positive (Staphylococcus aueruse).
American Psychological Association (APA)
Hasan, Ayat Naji& Abd, Dawud Salim. 2017. Preparation, characterization and biological activity study of some new thiazolidine derivatives. Journal of Basrah Researches : Sciences،Vol. 43, no. 1A, pp.10-29.
https://search.emarefa.net/detail/BIM-878153
Modern Language Association (MLA)
Hasan, Ayat Naji& Abd, Dawud Salim. Preparation, characterization and biological activity study of some new thiazolidine derivatives. Journal of Basrah Researches : Sciences Vol. 43, no. 1A (2017), pp.10-29.
https://search.emarefa.net/detail/BIM-878153
American Medical Association (AMA)
Hasan, Ayat Naji& Abd, Dawud Salim. Preparation, characterization and biological activity study of some new thiazolidine derivatives. Journal of Basrah Researches : Sciences. 2017. Vol. 43, no. 1A, pp.10-29.
https://search.emarefa.net/detail/BIM-878153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 28
Record ID
BIM-878153