Study of the relation between serum osteoprotegerin and both bone mass density and vascular complications in patients with diabetes

Abstract EN

Background: the identification of the OPG \ RANKL \ RANK axis [Osteoprotegerin / Receptor Activator of Nuclear Factor Kappa B Ligand / RANK receptor axis ]has really contributed in understanding the exact physiology of the bone resorption \ bone formation coupling process.

Besides regulating bone mass, osteoprotegerin plays an essential role in immune and vascular systems, s.

It is likely that the RANKL / RANK / OPG axis exerts important effects on the vascular system through both immunomodulatory and osteogenesis related mechanisms. Diabetes has been the subject of study in relation to the OPG \ RANKL \ RANK axis).

Beside the vascular complications of diabetes there exist diabetic osteopathy, there is now strong evidence that type 1 and type 2 diabetic patients have increased risk of certain types of fractures.