The effects of omega-3 and Vitamin E Co-supplementation on carotid intima-media thickness and inflammatory factors in patients with polycystic ovary syndrome

Abstract EN

Objectives: We sought to evaluate the effects of omega-3 and vitamin E cosupplementation on carotid intima-media thickness (CIMT) and inflammatory factors in patients with polycystic ovary syndrome (PCOS).

Methods: This randomized, doubleblind, placebo-controlled trial was done among 60 women with PCOS.

Participants were randomly assigned into two groups (n = 30 each group) and assigned to take either 1000 mg omega-3 plus 400 IU vitamin E supplements or a placebo for 12 weeks.

Results: Compared with placebo, omega-3 and vitamin E co-supplementation led to significant decreases in maximum levels of left CIMT (-0.006±0.006 vs.

+0.002±0.007 mm, p < 0.001), mean levels of left CIMT (-0.005±0.006 vs.

+0.002±0.010 mm, p = 0.010), maximum levels of right CIMT (-0.006±0.010 vs.

+0.006±0.010 mm, p = 0.010), and mean levels of right CIMT (-0.005±0.005 vs.

+0.001±0.010 mm, p = 0.020).

Change in high-sensitivity C-reactive protein (hs-CRP) (-390.6±942.9 vs.

+237.0±754.3 ng/mL, p = 0.006) was significantly different between the supplemented patients and placebo group.

We did not observe any significant effect in plasma nitric oxide (NO) values following supplementation with omega-3 plus vitamin E compared with the placebo.

Conclusions: Co-supplementation with omega-3 and vitamin E for 12 weeks among patients with PCOS had beneficial effects on CIMT and serum hs-CRP values, but unchanged NO values.