Delayed start protocol with gonadotropin-releasing hormone antagonist in poor responders undergoing in vitro fertilization : a randomized, double-blinded, clinical trial
Joint Authors
Zarei, Afsoon
Parsanezhad, Muhammad Ibrahim
Kutenaei, Maryam Uzayzi
Jahromi, Bahia Namavar
Isfahani, Parastoo Suhayl
Bakhshaei, Pardis
Source
Issue
Vol. 33, Issue 6 (30 Nov. 2018), pp.506-511, 6 p.
Publisher
Publication Date
2018-11-30
Country of Publication
Oman
No. of Pages
6
Main Subjects
Abstract EN
Objectives: We sought to determine the effects of the delayed start protocol with gonadotropin-releasing hormone (GnRH) antagonists in poor responders undergoing in vitro fertilization (IVF).
Methods: This randomized clinical trial was conducted during a 15-month period from April 2014 to July 2015 in clinics in Shiraz, Iran.
A total of 42 poor responders with primary infertility were randomly assigned to the controlled ovarian stimulation group utilizing the delayed start protocol (n = 21) or the traditional group (n = 21) using GnRH antagonist, Cetrotide.
The primary endpoint was the number of patients undergoing oocyte pick-up, implantation, and the rate of pregnancy.
Results: The baseline characteristics of the two study groups were comparable including age, infertility duration, and body mass index.
The number of follicles measuring > 13 mm in diameter (p = 0.057), retrieved oocytes (p = 0.564), mature metaphase II oocytes (p = 0.366), embryos (p = 0.709), and transferred embryos (p = 0.060) were comparable between the two groups.
The number of patients undergoing oocyte pickup (p = 0.311), the rates of implantation (p = 0.407), and pregnancy (p = 0.596) were also comparable between the two groups.
Conclusions: The delayed start protocol was not associated with better conception results or cycle outcomes in poor responders with primary infertility undergoing IVF cycles.
American Psychological Association (APA)
Zarei, Afsoon& Parsanezhad, Muhammad Ibrahim& Kutenaei, Maryam Uzayzi& Jahromi, Bahia Namavar& Isfahani, Parastoo Suhayl& Bakhshaei, Pardis. 2018. Delayed start protocol with gonadotropin-releasing hormone antagonist in poor responders undergoing in vitro fertilization : a randomized, double-blinded, clinical trial. Oman Medical Journal،Vol. 33, no. 6, pp.506-511.
https://search.emarefa.net/detail/BIM-880702
Modern Language Association (MLA)
Zarei, Afsoon…[et al.]. Delayed start protocol with gonadotropin-releasing hormone antagonist in poor responders undergoing in vitro fertilization : a randomized, double-blinded, clinical trial. Oman Medical Journal Vol. 33, no. 6 (Nov. 2018), pp.506-511.
https://search.emarefa.net/detail/BIM-880702
American Medical Association (AMA)
Zarei, Afsoon& Parsanezhad, Muhammad Ibrahim& Kutenaei, Maryam Uzayzi& Jahromi, Bahia Namavar& Isfahani, Parastoo Suhayl& Bakhshaei, Pardis. Delayed start protocol with gonadotropin-releasing hormone antagonist in poor responders undergoing in vitro fertilization : a randomized, double-blinded, clinical trial. Oman Medical Journal. 2018. Vol. 33, no. 6, pp.506-511.
https://search.emarefa.net/detail/BIM-880702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 510-511
Record ID
BIM-880702