Benefit of therapeutic drug monitoring of vancomycin in a respiratory ICU patient with acute kidney injury : a case report
Joint Authors
Zhang, Yong
Kong, Lingti
Zhu, Yulin
Liu, Haitao
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 21, Issue 4 (30 Apr. 2019), pp.1-3, 3 p.
Publisher
Publication Date
2019-04-30
Country of Publication
United Arab Emirates
No. of Pages
3
Main Subjects
Topics
Abstract EN
Introduction: Vancomycin damage to the kidney is one of the severe adverse reactions.
The primary objective of this study was to discuss how the clinical pharmacists should deal with the results of therapeutic drug monitoring (TDM) for Vancomycin.
Case Presentation: A case of severe acute kidney injury in a 60-year-old woman receiving Vancomycin as empirical therapy is reported here.
The patient was admitted to the respiratory intensive care unit (RICU) of the First Affiliated Hospital of Bengbu Medical College, China, on 15 Oct 2015.
On Day 7, the steady-state serum trough concentration and peak concentration of Vancomycin were 102.2 and 111.9 µg/mL, respectively.
Clinical pharmacists immediately contacted the clinicians and advised them to discontinue Vancomycin therapy as soon as possible, and the proposal was adopted.
On Day 8, serum creatinine (SCr) increased to 719 µmol/L, and creatinine clearance rate (CrCl) decreased to 6 mL/min; then, the patient was given dialysis treatment.
After she underwent dialysis treatment, SCr decreased to 330 µmol/L and CrCl increased to 14 mL/min on Day 19; then, the patient was discharged after she accepted the doctor’s advice to start a home-dialysis program outside the hospital.
Conclusions: In this case, clinical pharmacists contacted the doctor to avoid further aggravated renal damage timely when they found a significant increase in Vancomycin concentrations.
It indicates that the Vancomycin level can be used as an indirect marker of renal function as increased Vancomycin level results from and contributes to acute kidney injury
American Psychological Association (APA)
Kong, Lingti& Zhu, Yulin& Zhang, Yong& Liu, Haitao. 2019. Benefit of therapeutic drug monitoring of vancomycin in a respiratory ICU patient with acute kidney injury : a case report. Iranian Red Crescent Medical Journal،Vol. 21, no. 4, pp.1-3.
https://search.emarefa.net/detail/BIM-883766
Modern Language Association (MLA)
Kong, Lingti…[et al.]. Benefit of therapeutic drug monitoring of vancomycin in a respiratory ICU patient with acute kidney injury : a case report. Iranian Red Crescent Medical Journal Vol. 21, no. 4 (Apr. 2019), pp.1-3.
https://search.emarefa.net/detail/BIM-883766
American Medical Association (AMA)
Kong, Lingti& Zhu, Yulin& Zhang, Yong& Liu, Haitao. Benefit of therapeutic drug monitoring of vancomycin in a respiratory ICU patient with acute kidney injury : a case report. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 4, pp.1-3.
https://search.emarefa.net/detail/BIM-883766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3
Record ID
BIM-883766